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We investigate the essence of osseointegration and biointegration in the cell

Research Project

Project/Area Number 15K15741
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

MIYAMOTO Youji  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (20200214)

Co-Investigator(Kenkyū-buntansha) 玉谷 哲也  徳島大学, 病院, 講師 (30274236)
高丸 菜都美  徳島大学, 病院, 助教 (40513031)
永井 宏和  東北大学, 歯学研究科, 准教授 (50282190)
大江 剛  徳島大学, 病院, 助教 (60432762)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsイオンプレーティング法 / マイクロアレイ解析 / マウス骨芽細胞様細胞 / ヒト骨髄間葉系幹細胞 / スパッタ法
Outline of Final Research Achievements

Human mesenchymal stem cell (h-MSC) and MC3T3-E1cells were cultured on the glass dishes which were coated by titanium, gold or stainless steel. And the change of the genes and micro RNA (miRNA) expressions by cell cultures on those different dishes were analyzed by the microarray assay. We identified 2 genes and 5 miRNA in h-MSC cultured on titan coated dishes more than twice expression as comparison with cell cultured on other dishes.
We also found the half or less expression of 2 genes and 2 miRNA decreased by cell culture on titan coated dishes. Similarly, in MC3T3-E1cells, we identified genes and miRNA related with cell attachment on titan.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] A case of tophaceous pseudogout of the temporomandibular joint extending to the base of the skull2017

    • Author(s)
      Keiko Kudoh, Takaharu Kudoh and Youji Miyamoto
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery

      Volume: 46 Issue: 3 Pages: 355-359

    • DOI

      10.1016/j.ijom.2016.08.018

    • NAID

      120006501913

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allergic contact dermatitis caused by titanium screws and dental implants2016

    • Author(s)
      Hosoki M, Nishigawa K, Miyamoto Y, Ohe G, Matsuka Y
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 3 Pages: 213-219

    • DOI

      10.1016/j.jpor.2015.12.004

    • NAID

      130005172067

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Measurement of the zygomatic bone and pilot hole technique for safer insertion of zygomaticus implants2016

    • Author(s)
      Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Tetsuya Tamatani, Kaori Sumida, Seiichiro Kitamura, Youji Miyamoto
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery

      Volume: 45 Pages: 104-109

    • NAID

      120006847346

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and imaging characteristics of palatine tonsilloliths evaluated on 2244 pairs of panoramic radiographs and CT images2016

    • Author(s)
      Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Go Ohe, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto
    • Journal Title

      Clinical Oral Investigations

      Volume: 21-1 Issue: 1 Pages: 85-91

    • DOI

      10.1007/s00784-016-1752-0

    • NAID

      120006714438

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and physical evaluation of gelatin-coated carbonate apatite foam2016

    • Author(s)
      Kanae Hara, Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, Go Ohe, Kanji Tsuru, Kunio Ishikawa and Youji Miyamoto
    • Journal Title

      Materials

      Volume: 1 Issue: 9 Pages: 711-711

    • DOI

      10.3390/ma9090711

    • NAID

      120006715985

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低結晶性炭酸アパタイトを用いた骨再建に関する基礎的研究2016

    • Author(s)
      大江 剛,藤澤 健司,永井 宏和,宮本 洋二
    • Organizer
      第20回公益社団法人日本顎顔面インプラント学会総会・学術大会
    • Place of Presentation
      東京医科歯科大学M&Dタワー(東京都・文京区)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] チタン上で培養したヒト骨髄間葉系幹細胞の遺伝子およびmicroRNA発現の解析2016

    • Author(s)
      山村佳子, 玉谷哲也, 大江 剛, 藤澤健司, 高丸菜都美, 工藤景子, 永井宏和, 宮本洋二
    • Organizer
      第61回(公社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉県・幕張市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] チタンが培養ヒト骨髄間葉系幹細胞に及ぼす影響 マイクロアレイによる解析2016

    • Author(s)
      山村佳子, 玉谷哲也, 大江剛, 藤澤健司, 高丸菜都美, 工藤景子, 永井宏和, 宮本洋二
    • Organizer
      日本バイオマテリアル学会 シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるSOX2発現の臨床病理学的意義2016

    • Author(s)
      玉谷哲也, 高丸菜都美, 永井宏和, 宮本洋二
    • Organizer
      第75回日本癌学会学術大会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 炭酸アパタイト被膜炭酸カルシウムを用いた新規骨置換材料による骨再生の試み2016

    • Author(s)
      大江剛, 小林真左子, 藤澤健司, 永井宏和, 宮本洋二
    • Organizer
      第46回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低結晶性炭酸アパタイトのインプラント領域への応用 イヌ顎骨への印プラント体との同時埋植2016

    • Author(s)
      藤澤健司, 永井宏和, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二
    • Organizer
      第46回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of ALDH1, Bmi-1 and CD24 in human oral squamous cell carcinoma and its relationship with clinical factors2016

    • Author(s)
      Tetsuya Tamatani, Natsumi Takamaru, Kenji Fujisawa, Hirokazu Nagai, Youji Miyamoto
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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