| Project/Area Number |
15K15742
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中城 公一 愛媛大学, 医学系研究科, 准教授 (90314880)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 口腔癌 / Ｂ細胞 / CXCL13 / 口腔扁平上皮癌 / B細胞 |
|---|
| Outline of Final Research Achievements |
Recently, immunotherapy has attracted attention as a novel treatment with cancer, and immunocheck point inhibitors against T cells and antibodies inducing ADCC activity of NK cells are used in clinical setting. In this study, the significance of B cells in oral cancer was examined. Assessment of the relationship between the number of B cells in oral cancer tissues by immunohistochemical staining and the survival rate revealed that the prognosis was better as B cells more invaded the cancer stroma. Furthermore, CXCL13, a B cell attracting cytokine, was highly expressed in the cancerous tissues as compared with the adjacent normal tissues.
|
