Localization and function of B cells in oral cancer

• Project/Area Number: 15K15742
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: Hamakawa Hiroyuki 愛媛大学, 医学系研究科, 教授 (20127905)
• Co-Investigator(Kenkyū-buntansha): 中城 公一 愛媛大学, 医学系研究科, 准教授 (90314880)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔癌 / Ｂ細胞 / CXCL13 / 口腔扁平上皮癌 / B細胞

Outline of Final Research Achievements

Recently, immunotherapy has attracted attention as a novel treatment with cancer, and immunocheck point inhibitors against T cells and antibodies inducing ADCC activity of NK cells are used in clinical setting. In this study, the significance of B cells in oral cancer was examined. Assessment of the relationship between the number of B cells in oral cancer tissues by immunohistochemical staining and the survival rate revealed that the prognosis was better as B cells more invaded the cancer stroma. Furthermore, CXCL13, a B cell attracting cytokine, was highly expressed in the cancerous tissues as compared with the adjacent normal tissues.

Research Products

• [Journal Article] Objective validity of an implant-retained overdenture with a ball attachment system after marginal mandibulectomy (2016)
  • Author(s): Murase R, Ishikawa A, Sumida T, Shinohara K, Nakashiro K, Hamakawa H
  • Journal Title: Br J Oral Maxillofac Surg Volume: 54 Issue: 2 Pages: e21-e25
  • DOI: 10.1016/j.bjoms.2015.11.017
  • Peer Reviewed
• [Journal Article] Annexin A8 is a novel molecular marker for detecting lymph node metastasis in oral squamous cell carcinoma. (2016)
  • Author(s): Oka R, Nakashiro K, Goda H, Iwamoto K, Tokuzen N, Hamakawa H.
  • Journal Title: oncotarget Volume: 7(4) Issue: 4 Pages: 4882-9
  • DOI: 10.18632/oncotarget.6639
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma (2016)
  • Author(s): Tokuzen N, Nakashiro K, Tanaka H, Iwamoto K, Hamakawa H
  • Journal Title: Oncotarget Volume: 7 Issue: 3 Pages: 2343-53
  • DOI: 10.18632/oncotarget.6148
  • Peer Reviewed / Open Access
• [Journal Article] Clinical implication of blood glucose monitoring in general dental offices: the Ehime Dental Diabetes Study (2015)
  • Author(s): Harase T, Nishida W, Hamakawa T, Hino S, Shigematsu K, Kobayashi S, Sako H, Ito S, Murakami H, Nishida K, Inoue H, Fujisawa M, Yoshizu H, Kawamura R, Takata Y, Onuma H, Shimizu K, Hamakawa H, Osawa H
  • Journal Title: BMJ Open Diabetes Res Care Volume: 3 Issue: 1 Pages: e000151-e000151
  • DOI: 10.1136/bmjdrc-2015-000151
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Akt1 as a potent therapeutic target for oral squamous cell carcinoma (2015)
  • Author(s): Nakashiro K, Tanaka H, Goda H, Iwamoto K, Tokuzen N, Hara S, Onodera J, Fujimoto I, Hino S, Hamakawa H
  • Journal Title: Int J Oncol Volume: 47 Issue: 4 Pages: 1273-81
  • DOI: 10.3892/ijo.2015.3134
  • Peer Reviewed
• [Journal Article] Dental Implants in Oral Rehabilitation of A Maxillary Cancer Reconstruction: A Case Report (2015)
  • Author(s): Sumida T, Nakano H, Hamakawa H, Mori Y
  • Journal Title: J Oral Implantol Volume: 41 Issue: 6 Pages: 737-9
  • DOI: 10.1563/aaid-joi-d-13-00136
  • Peer Reviewed
• [Journal Article] A Clinical Investigation of Oral Sarcomas at Multi-institutions Over the Past 30 Years (2015)
  • Author(s): Sumida T, Otawa N, Kamata YU, Yamada T, Uchida K, Nakano H, Hamakawa H, Yamamoto T, Ueyama Y, Mori Y
  • Journal Title: Anticancer Res Volume: 35 Pages: 4551-5
  • Peer Reviewed
• [Journal Article] Ribonucleotide reductase M2 is a promising molecular target for the treatment of oral squamous cell carcinoma. (2015)
  • Author(s): Iwamoto K, Nakashiro K, Tanaka H, Tokuzen N, Hamakawa H.
  • Journal Title: Int J Oncol. Volume: 46 Issue: 5 Pages: 1971-1977
  • DOI: 10.3892/ijo.2015.2912
  • Peer Reviewed / Open Access