• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional recovery of injured inferior alveolar nerve using peripheral glial cell line-derived neurotrophic factor

Research Project

Project/Area Number 15K15748
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

SHINODA Masamichi  日本大学, 歯学部, 准教授 (20362238)

Co-Investigator(Kenkyū-buntansha) 片桐 綾乃  大阪大学, 歯学研究科, 助教 (40731899)
岩田 幸一  日本大学, 歯学部, 教授 (60160115)
久保 亜抄子  日本大学, 歯学部, ポスト・ドクトラル・フェロー (70733202)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords神経再生 / GDNF / 下歯槽神経損傷
Outline of Final Research Achievements

We examined the involvement of peripheral glial cell line-derived neurotrophic factor (GDNF) application in the functional recovery of facial mechanical nociception following inferior alveolar nerve transection (IANX). GDNF was expressed in infiltrating inflammatory cells such as macrophages and neutrophils, and GDNF expression was enhanced in the IAN injured region. Continuous GDNF administration to the injury site enhanced axonal regeneration of IAN and recovery of nociceptive mechanical sensitivity of the facial skin. GDNF neutralization using a neutralizing antibody at the injury site inhibited the recovery of nociceptive mechanical sensitivity of the facial skin after IANX. GDNF signaling at the IANX site accelerates the functional recovery of mechanical nociception of the facial skin following IANX. Therefore, GDNF application at the IANX site may be an attractive therapeutic target for the functional disturbance of pain sensation of the facial skin following IANX.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Peripheral glial cell line-derived neurotrophic factor facilitates the functional recovery of mechanical nociception following inferior alveolar nerve transection in rats2018

    • Author(s)
      Watanabe M, Shinoda M, Batbold D, Sugano N, Sato S, Iwata K
    • Journal Title

      J Oral Facial Pain Headache.

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low-intensity pulsed ultrasound accelerates nerve regeneration following inferior alveolar nerve transection in rats.2016

    • Author(s)
      Sato M, Motoyoshi M, Shinoda M, Iwata K, Shimizu N.
    • Journal Title

      Eur J Oral Sci.

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Effect of Glial Cell Line-Derived Neurotrophic Factor Application on the Functional Recovery of Mechanical Nociception following Inferior Alveolar Nerve Transection in Rats2018

    • Author(s)
      Shinoda M, Watanabe M, Iwata K
    • Organizer
      American Pain Society Scientific Summit 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 下歯槽神経切除後の顔面皮膚感覚機能回復に対するGDNFの有用性2017

    • Author(s)
      渡辺雅弘,篠田雅路,岩田 幸一,菅野直之,佐藤秀一
    • Organizer
      第22回日本口腔顔面痛学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下歯槽神経切除後の顔面皮膚感覚機能回復に対するGDNFの有用性2016

    • Author(s)
      渡辺雅弘,篠田雅路,菅野直之,佐藤秀一,岩田幸一
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 下歯槽神経切除モデルにおける細胞移植の効果2015

    • Author(s)
      本田雅規,鳥海拓,岡篤志,篠田雅路,岩田幸一,磯川桂太郎
    • Organizer
      第57回歯科基礎医学会学術大会サテライトシンポジウム
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi