| Project/Area Number |
15K15757
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IZAWA Takashi 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (30380017)
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| Co-Investigator(Kenkyū-buntansha) |
田中 栄二 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (40273693)
岩浅 亮彦 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (90746025)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯学 / 歯科矯正学 / 骨代謝学 / 免疫学 / シグナル伝達 / 破骨細胞 / 骨芽細胞 / 骨リモデリング / 病理学 / 細胞・組織 |
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| Outline of Final Research Achievements |
The mechanism underlying the regulation of AhR expression in osteoclasts and the signaling pathway through which AhR controls osteoclastogenesis remain unclear. We found that the expression of AhR in bone marrow-derived osteoclasts was upregulated by RANKL at an earlier stage. Osteoclast differentiation mediated by the AhR signaling pathway was also regulated in a RANKL/c-Fos-dependent manner. AhR controls osteoclast differentiation via c-Fos/NFATc1 and mitochondrial biogenesis through PGC-1β.
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