| Project/Area Number |
15K15760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
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| Co-Investigator(Kenkyū-buntansha) |
田嶋 敦 金沢大学, 医学系, 教授 (10396864)
市川 雄大 昭和大学, 歯学部, 助教 (30635058)
山口 徹太郎 昭和大学, 歯学部, 准教授 (40384193)
権 佳奈 昭和大学, 歯学部, 助教 (50750650)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メチル化 / 顎顔面外科手術 / エピジェネティック / EWAS / 咬合 / DNAメチル化 / 矯正 |
|---|
| Outline of Final Research Achievements |
We observed the influence of maxillofacial surgery on genome - wide methylation in saliva. Maxillofacial Surgery prior to surgery and 3 months after surgery, saliva of nine patients undergoing maxillofacial surgery and two controls were sampled. Genome-wide DNA methylation profiling was performed using Infinium Human Methylation 450 Beadchips. Significant (P <0.05) DNA methylation changes were observed in more than 10,000 sites between preoperative and postoperative.
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