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Effects of chewing during prenatal stress on diabetes onset in mouse offspring

Research Project

Project/Area Number 15K15761
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagoya Women's University (2017)
Seijoh University (2015-2016)

Principal Investigator

Kubo Kin-ya  名古屋女子大学, 家政学部, 教授 (00329492)

Co-Investigator(Kenkyū-buntansha) 笹栗 健一  自治医科大学, 医学部, 講師 (10235286)
東 華岳  産業医科大学, 医学部, 教授 (20273146)
飯沼 光生  朝日大学, 歯学部, 教授 (70184364)
小野塚 実  神奈川歯科大学, 歯学部, 名誉教授 (90084780)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsprenatal stress / chewing / diabetes mellitus / adiposeness / fat / insullin resistance / 咀嚼運動 / 妊娠ストレス / 糖尿病 / 肥満 / ストレスコーピング
Outline of Final Research Achievements

Maternal stress induces decreased birth weights and glucose intolerance, leading to diabetes in the pups. We examined the effects of chewing during maternal restraint stress on changes in weight, blood glucose levels, and energy metabolism-related materials in the pup. Pregnant mice were exposed to restraint stress. Half of dams were given a wooden stick to chew during restraint stress. Restraint stress during pregnancy increased body weight, amount of food ingested, blood glucose levels, insulin resistance, plasma leptin levels and NPY mRNA expression, and decreased blood adiponectin levels in the adult pups. Adult offspring of dams allowed to chew during restraint stress exhibited decreased in body weight, amount of food ingested, blood glucose levels, insulin resistance, plasma leptin levels and NPY mRNA expression, and increased blood adiponectin levels. These findings suggest that maternal chewing ameliorates maternal stress-induced diabetes in the adult offspring.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Maternal Active Mastication during Prenatal Stress Ameliorates Prenatal Stress-Induced Lower Bone Mass in Adult Mouse Offspring2017

    • Author(s)
      Azuma K, Ogura M, Kondo H, Suzuki A, Hayashi S, Iinuma M, Onozuka M, Kubo KY
    • Journal Title

      Int J Med Sci

      Volume: 14 Issue: 4 Pages: 348-355

    • DOI

      10.7150/ijms.18298

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association between mastication, the hippocampus, and the HPA axis: a comprehensive review.2017

    • Author(s)
      Azuma K, Zhou Q, Niwa M, Kubo KY
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 8 Pages: 1867-1867

    • DOI

      10.3390/ijms18081687

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring2016

    • Author(s)
      Suzuki A, Iinuma M, Hayashi S, Sato Y, Azuma K, Kubo KY
    • Journal Title

      Brain Res

      Volume: 91 Pages: 36-43

    • DOI

      10.1016/j.brainres.2016.09.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant

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Published: 2015-04-16   Modified: 2019-03-29  

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