An analysis of therapeutic and functional efficiency of targeting Janus kinase and periodontal bacteria in patients with periodontitis and rheumatoid arthritis
| Project/Area Number |
15K15764
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 哲夫 新潟大学, 医歯学総合病院, 准教授 (00215344)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 歯周炎 / 関節リウマチ / JAK分子標的 / 抗菌療法 / 関節リュウマチ |
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| Outline of Final Research Achievements |
The aim of the present study was to assess the therapeutic and functional efficiency of targeting Janus kinase (JAK) and periodontal bacteria in patients with periodontitis and rheumatoid arthritis (RA). The results indicated that both the JAK- and the periodontal bacteria-targeting therapies exhibited an improvement of rheumatologic and periodontal inflammatory condition. The former therapies reduced serum levels of interleukin-6 and tumor necrosis factor, while the latter decreased serum protein spots in abundance which corresponds to blood and lipid metabolism-related components including apolipoprotein A1, angiotensinogen, and hemopexin. These results suggest the beneficial therapeutic effects of the JAK- and the periodontal bacteria-targeting therapies on rheumatologic and periodontal condition in patients with periodontitis and RA.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study.2018
Author(s)
Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
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Journal Title
J Periodontol
Volume: 89(3)
Issue: 3
Pages: 315-324
DOI
Related Report
Peer Reviewed / Open Access
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