| Project/Area Number |
15K15766
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kurihara Hidemi 広島大学, 医歯薬保健学研究院(歯), 教授 (40161765)
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| Co-Investigator(Kenkyū-buntansha) |
二川 浩樹 広島大学, 医歯薬保健学研究院(歯), 教授 (10228140)
應原 一久 広島大学, 医歯薬保健学研究院(歯), 助教 (80550425)
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| Research Collaborator |
FUJITA Tsuyoshi 広島大学, 大学院・医歯薬保健学研究院(歯), 准教授
SUGIYAMA Eiji 広島大学, 大学院・医歯薬保健学研究院(医), 教授
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周炎 / バクテリミア / 腸内細菌叢 / 関節リウマチ / バクテレミア |
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| Outline of Final Research Achievements |
In this study, the involvement of periodontitis (periodontopathogenic bacteria, Porphyromonas gingivalis infection) in the progression of rheumatoid arthritis (RA) was determined by using the model mouse of RA (SKG mouse).The oral infection of P. gingivalis induced RA strongly in SKG mice same as the intraperitoneal infection (Yamakawa et. al. 2015 CEI). The dysbiosis by P. gingivalis showed the increase of population of bacteroides bacteria by analyzing Miseq (illumina). The elevation of IgA in feces was observed in the group of P. gingivalis infected RA mouse. The enzyme AID for the class-switching of iGM to IgA was also upregulated in peyer's patches. These findings indicates that the infection of P. gingivalis via oral cavity might cause of induction of systemic disease by changeng the bacterial environment in gut.
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