| Project/Area Number |
15K15768
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Ohu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山口 洋子 日本大学, 歯学部, 助教 (00239922)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 歯周炎 / 生体外歯周炎モデル / HGF / miRNA / FLT1 / 線維芽細胞 |
|---|
| Outline of Final Research Achievements |
We have made a list of candidate genes for periodontitis using gene expression profiling data of in vitro periodontitis model which includes periodontitis causative fibroblasts. Inhibiting candidate genes products, collagen degradation was significantly decreased. It will make possible to molecular targeted therapy for periodontitis for the first time. We also demonstrated that periodontitis-causative fibroblasts are clearly different from normal gingival fibroblasts supported by RIKEN FANTOM5 Project, and established a detection method by PCR.
|
