A study on exploratory identification of responsive subgroups in complex survival event data
| Project/Area Number |
15K15950
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Statistical science
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| Research Institution | Keio University |
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Principal Investigator |
Hayashi Kenichi 慶應義塾大学, 理工学部(矢上), 講師 (70617274)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 医学統計学 / 区間打ち切りデータ / C-index / IDI / NRI / ROC解析 / power-IDI / クラスタワイズ回帰モデル / DIDI / AUC |
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| Outline of Final Research Achievements |
This project aims to develop measures of statistical model for survival outcomes and related variables such as biomarkers, and methods that detects responsive subgroups in data. As for the first issue, an estimation method of C-index for interval censored data is proposed. Further, a modification of the IDI (integrated discriminant improvement) is developed to overcome critical concerns in the original IDI. As for the second issue, a cluster-wise linear model is extended based on the generalized mean, which is called Kolmogorov-Nagumo average. The extended model involves several models proposed in the previous study as special caes. Through numerical experiments, the superiority of the proposed model is implied.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Injustice Experience Questionnaire, Japanese Version: Cross-Cultural Factor-Structure Comparison and Demographics Associated with Perceived Injustice.2016
Author(s)
Yamada K, Adachi T, Mibu A, Nishigami T, Motoyama Y, Uematsu H, Matsuda Y, Sato H, Hayashi K, Cui R, Takao Y, Shibata M, Iso H
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Journal Title
PloS One
Volume: 11
Issue: 8
Pages: e0160567-e0160567
DOI
Related Report
Peer Reviewed / Open Access
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