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A study on exploratory identification of responsive subgroups in complex survival event data

Research Project

Project/Area Number 15K15950
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Research InstitutionKeio University

Principal Investigator

Hayashi Kenichi  慶應義塾大学, 理工学部(矢上), 講師 (70617274)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords医学統計学 / 区間打ち切りデータ / C-index / IDI / NRI / ROC解析 / power-IDI / クラスタワイズ回帰モデル / DIDI / AUC
Outline of Final Research Achievements

This project aims to develop measures of statistical model for survival outcomes and related variables such as biomarkers, and methods that detects responsive subgroups in data. As for the first issue, an estimation method of C-index for interval censored data is proposed. Further, a modification of the IDI (integrated discriminant improvement) is developed to overcome critical concerns in the original IDI. As for the second issue, a cluster-wise linear model is extended based on the generalized mean, which is called Kolmogorov-Nagumo average. The extended model involves several models proposed in the previous study as special caes. Through numerical experiments, the superiority of the proposed model is implied.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Asymptotic comparison of semi-supervised and supervised linear discriminant functions for heteroscedastic normal populations2018

    • Author(s)
      Kenichi Hayashi
    • Journal Title

      Advances in Data Analysis and Classification

      Volume: - Issue: 2 Pages: 315-339

    • DOI

      10.1007/s11634-016-0266-6

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of a concordance probability for doubly censored time-to-event data2018

    • Author(s)
      Kenichi Hayashi, Yasutaka Shimizu
    • Journal Title

      Statistics in Biosciences

      Volume: - Issue: 3 Pages: 546-567

    • DOI

      10.1007/s12561-018-9216-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between cell-mediated immunity to Varicella-Zoster virus and aging in subjects from the community-based Shozu Herpes Zoster study2017

    • Author(s)
      Risako Shirane, Huamin Tang, Kenichi Hayashi, Yoshinobu Okuno, Hiroyasu Iso, Hideo Asada, Koichi Yamanishi, Yasuko Mori
    • Journal Title

      Journal of Medical Virology

      Volume: 89 Issue: 2 Pages: 313-317

    • DOI

      10.1002/jmv.24629

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcomes differ by first documented rhythm after witnessed out-of-hospital cardiac arrest in children; an observational study with prospective nationwide population-based cohort database in Japan2016

    • Author(s)
      Hara M, Hayashi K, Kitamura T
    • Journal Title

      European Heart Journal - Quality of Care and Clinical Outcomes

      Volume: 3 Issue: 1 Pages: 83-92

    • DOI

      10.1093/ehjqcco/qcw040

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Injustice Experience Questionnaire, Japanese Version: Cross-Cultural Factor-Structure Comparison and Demographics Associated with Perceived Injustice.2016

    • Author(s)
      Yamada K, Adachi T, Mibu A, Nishigami T, Motoyama Y, Uematsu H, Matsuda Y, Sato H, Hayashi K, Cui R, Takao Y, Shibata M, Iso H
    • Journal Title

      PloS One

      Volume: 11 Issue: 8 Pages: e0160567-e0160567

    • DOI

      10.1371/journal.pone.0160567

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clustering of multivariate binary data with dimension reduction via L1-regularized likelihood maximization2015

    • Author(s)
      Michio Yamamoto, Kenichi Hayashi
    • Journal Title

      Pattern Recognition

      Volume: 48 Issue: 12 Pages: 3959-3968

    • DOI

      10.1016/j.patcog.2015.05.026

    • NAID

      120005690145

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different Impacts of Time From Collapse to First Cardiopulmonary Resuscitation on Outcomes After Witnessed Out-of-Hospital Cardiac Arrest in Adults2015

    • Author(s)
      Masahiko Hara, Kenichi Hayashi, SHungo Hikoso, Yasushi Sakata, Tetsuhisa Kitamura
    • Journal Title

      Circulation: Cardiovascular Quality and Outcomes

      Volume: 未定 Issue: 3 Pages: 277-284

    • DOI

      10.1161/circoutcomes.115.001864

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Body Size on Inferior Vena Cava Parameters for Estimating Right Atrial Pressure: A Need for Standardization?2015

    • Author(s)
      Tatsunori Taniguchi, Tomohiro Ohtani, Satoshi Nakatani, Kenichi Hayashi, Osamu Yamaguchi, Issei Komuro, Yasushi Sakata
    • Journal Title

      Journal of the American Society of Echocardiography

      Volume: 28 Issue: 12 Pages: 1420-1427

    • DOI

      10.1016/j.echo.2015.07.008

    • Related Report
      2015 Research-status Report
  • [Journal Article] Finite-sample analysis of impacts of unlabelled data and their labelling mechanisms in linear discriminant analysis2014

    • Author(s)
      Kenichi Hayashi, Keiji Takai
    • Journal Title

      Communications in Statistics -Simulation and Computation

      Volume: - Issue: 1 Pages: 184-203

    • DOI

      10.1080/03610918.2014.957847

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 中間事象を伴う臨床試験における複合ストラテジーの検討2018

    • Author(s)
      田栗正隆,林賢一
    • Organizer
      日本計量生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 擬似値に基づく競合リスクイベントデータ解析における変数選択規準2018

    • Author(s)
      田島史啓
    • Organizer
      日本計量生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Semi-supervised learning for normal populations: a perspective from statistical missing data analysis2017

    • Author(s)
      Kenichi Hayashi
    • Organizer
      The 2017 Conference of International Federation of Classification
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cluster-wise regression models via a quasi-linear function2017

    • Author(s)
      Kenichi Hayashi
    • Organizer
      The International Association of Statistical Computing (Asian Regional Section) Joint Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cluster-wise regression models via a quasi-linear function2017

    • Author(s)
      林賢一,江口真透
    • Organizer
      統計関連学会連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Modification of integrated discrimination improvement by beta divergence2016

    • Author(s)
      Kenichi Hayashi, Shinto Eguchi
    • Organizer
      The 28th International Biometric Conference
    • Place of Presentation
      Victoria (Canada)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] MARデータにおける変数の部分集合に対する情報量規準2016

    • Author(s)
      林賢一,高井啓二
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Integrated discrimination improvementの問題点とその修正2016

    • Author(s)
      林賢一,江口真透
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Computing C-statistic with interval censored data2015

    • Author(s)
      Kenichi Hayashi
    • Organizer
      The 8th International Conference of the ERCIM WG on Computational and Methodological Statistics
    • Place of Presentation
      London (UK)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] An information criterion for a subset of MAR data2015

    • Author(s)
      Keiji Takai, Kenichi Hayashi
    • Organizer
      The 8th International Conference of the ERCIM WG on Computational and Methodological Statistics
    • Place of Presentation
      London (UK)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 機械学習 データを読み解くアルゴリズムの技法2017

    • Author(s)
      ピーター フラッハ (著),竹村 彰通 (監修),田中 研太郎 (翻訳),小林 景 (翻訳),兵頭 昌 (翻訳),片山 翔太 (翻訳),山本 倫生 (翻訳),吉田 拓真 (翻訳),林 賢一 (翻訳),松井 秀俊 (翻訳),小泉 和之 (翻訳),永井 勇 (翻訳)
    • Total Pages
      392
    • Publisher
      朝倉書店
    • ISBN
      9784254122183
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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