| Project/Area Number |
15K16082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Ishida Takashi 東京工業大学, 情報理工学院, 准教授 (40508355)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | トリパノソーマ寄生原虫症 / タンパク質立体構造予測 / 適合性フィードバック / 創薬標的タンパク質選定 / 顧みられない熱帯病 / シャーガス病 / 創薬標的タンパク質選択 / ランキング学習 / タンパク質ポケット探索 / タンパク質立体構造 |
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| Outline of Final Research Achievements |
We constructed protein structure models for whole proteins encoded on genome of trypanosoma cruzi, which is a pathogenic agent of Chagas' disease, by using homology modeling technique. We also developed web-interface for accessing those structure models, and enabled drug discovery researchers to find more suitable target using protein structure information. In addition, we developed a new system to help the user find their demanded targets more efficiently based on relevance feedback and learning-to-rank.
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