Computational analysis of low-dose radiation responses based on artificial neural network

• Project/Area Number: 15K16088
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: Tokyo Institute of Technology (2016); Japan Atomic Energy Agency (2015)
• Principal Investigator: Hattori Yuya 東京工業大学, 工学院, 助教 (30709803)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 放射線生物 / 数理生物 / 数理解析 / 低線量放射線応答 / 放射線 / 培養細胞 / バイスタンダー効果 / ニューラルネットワーク / シミュレーション

Outline of Final Research Achievements

The purpose of this study is to understand the mechanism of low-dose radiation response in cellular population related to evaluations of radiation risks. We developed a mathematical model which can calculate temporal and spatial intercellular signaling and radiation responses of individual cells.
Our model successfully reproduced radiation responses of experimental data previously reported. The model also showed non-linear characteristics of low-dose radiation response.

Research Products

• [Journal Article] Cellular automaton-based model for radiation-induced bystander effects (2015)
  • Author(s): Yuya Hattori, Akinari Yokoya and Ritsuko Watanabe
  • Journal Title: BMC Systems Biology Volume: 9 Issue: 1 Pages: 1-22
  • DOI: 10.1186/s12918-015-0235-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 放射線影響解明のための計算論的アプローチ～細胞間コミュニケーションに関する解析～ (2017)
  • Author(s): 服部 佑哉
  • Organizer: 平成29年東京RBC新春放談会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2017-02-04
  • Invited
• [Presentation] 放射線誘発バイスタンダー効果の統合的な解析のためのシミュレーションアプローチ (2016)
  • Author(s): 服部 佑哉
  • Organizer: 東京工業大学先導原子力研究所コロキウム
  • Place of Presentation: 東京都目黒区
  • Year and Date: 2016-05-16
  • Invited
• [Presentation] A mathematical model of modification of cell-cycle progression by radiation-induced bystander effects (2015)
  • Author(s): Yuya Hattori, Akinari Yokoya, Ritsuko Watanabe
  • Organizer: 12th International Workshop on Microbeam Probes of Cellular Radiation Response (IWM2015)
  • Place of Presentation: 若狭湾エネルギー研究センター（福井県敦賀市）
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Simulation study of individual cellular responses by bystander effects in cellular population (2015)
  • Author(s): Yuya Hattori, Akinari Yokoya, Ritsuko Watanabe
  • Organizer: 15th International Congress of Radiation Research (ICRR2015)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-05-25
  • Int'l Joint Research