| Project/Area Number |
15K16089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Saito Yutaka 国立研究開発法人産業技術総合研究所, 人工知能研究センター, 研究員 (60721496)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ゲノム3D構造 / エピゲノム / HiC/3C / ゲノム3次元構造 / HiC / 3C / 共局在遺伝子 / バイオインフォマティクス |
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| Outline of Final Research Achievements |
We developed Cosearge, a bioinformatics method for finding 3D co-localization of genomic elements from HiC data. We applied Cosearge to HiC data from embryonic stem cells, and detected a number of novel co-localized genes distinct from topologically associated domains proposed in existing studies. In particular, we found that SOX2 and DNA damage response genes are co-localized in embryonic stem cells.
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