| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Anti-cancer drug camptothecin (CPT) causes DNA double-strand break (DSB) containing a single-DNA end that is referred to as one-ended DSB. Given that contribution of non-homologous end joining (NHEJ) to the repair of one-ended DSBs are considered to sensitize cells to CPT, it is important to reveal the mechanism of NHEJ contribution to the repair of one-ended DSBs for consideration of CPT efficacy in the chemotherapy.
Several researches suggested that UbcH5 is involved in the appearance of chromosome aberrations and CPT-resistance via NHEJ. SIAH1 was also identified as E3 ubiquitin ligase that is involved in NHEJ activation, but it has showed different phenotypes from UbcH5 so far.
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