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The role of cholesterol hydroxylase against methylmercury-induced neurotoxic effects

Research Project

Project/Area Number 15K16133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Iwai-Shimada Miyuki  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 研究員 (80723957)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsメチル水銀 / コレステロール
Outline of Final Research Achievements

Methylmercury is an environmental contaminant with a selective toxicity for the central nervous system. However, the mechanism of toxicity selective to the nervous system is not well understood. The mRNA expression of CH25H was specifically increased in the brain by administration of methylmercury. On the double staining of immunostaining and in situ hybridaztion, CH25H mRNA expression was observed in GFAP positive cell on the mouse brain. Moreover, we found that the knockdown of CH25H increased the toxicity of methylmercury in C17.2 cells, BV2 cells and C8-D1A cells. These results are suggesting that the CH25H plays a key role in the defense mechanism against toxicity of methylmercury.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (2 results) (of which Invited: 1 results) Book (1 results)

  • [Presentation] メチル水銀曝露によるマウス脳内でのコレステロール25-水酸化酵素の発現誘導とその意義2016

    • Author(s)
      岩井美幸, 黄基旭, 金ミンソク, 高橋勉, 永沼章
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胎児期の残留性有機汚染物質曝露と出生体重および発達との関連性2015

    • Author(s)
      岩井美幸, 龍田希, 黒川修行, 仲井邦彦, 永沼章, 佐藤洋
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 衛生・公衆衛生学 社会や環境のシステムと健康との関わり2016

    • Author(s)
      岩井美幸
    • Publisher
      アイ・ケイコーポレーション
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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