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relationships between debromination and urea synthesizability on metabolism of xenobiotics by fish

Research Project

Project/Area Number 15K16134
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

MIZUKAWA Kaoruko  東京農工大学, (連合)農学研究科(研究院), 助教 (50636868)

Research Collaborator Takada Hideshige  東京農工大学
Stegeman John J.  Woods Hole Oceanographic Institution
Goldstone Jed V.  Woods Hole Oceanographic Institution
Salanga Matthew C.  Arizona University
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsPBDEs / 脱臭素化 / 魚類 / 異物代謝 / 甲状腺ホルモン / 脱ヨウ素酵素 / 微量汚染物質 / 種差 / ハゼ科 / ドジョウ亜科 / BDE99 / コイ目
Outline of Final Research Achievements

Debromination of PBDEs by fish has been considered that it would be caused by deiodinase which is the enzyme for activation of thyroid hormones. The aim of the study is to compare species specific debromination of PBDEs and reveal the factor. It is important knowledge for metabolic sensitivity of xenobiotics. BDE99 is the most debrominatable congener of PBDE. To compare accumulation of BDE99 in muscle tissues and debromination ability of BDE99 by hepatic microsome among many kinds of fishes, wild fishes were collected from Tama River and coastal area of Tokyo Bay, Japan. Some fishes had no BDE99 accumulation in their muscle tissues and had debromination ability of BDE99 by hepatic microsome. Especially the all 12 Cyprinidae indicated the relationships throughout the family. However there are no consistent relationships among 6 Gobidae. It is suggested that the difference of the debromination velocity of BDE99 among species are due to enzymatic structures of deiodinase.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] Woods Hole Oceanographic Institute(米国)

    • Related Report
      2016 Research-status Report
  • [Presentation] Species specific debromination of PBDEs and relationships to deiodinase2017

    • Author(s)
      Mizukawa K., Yokota K., Takada H., Salanga M., Goldstone J., Stegeman J.
    • Organizer
      8th International Symposium on Flame Retardants
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SPECIES SPECIFIC DEBROMINATION OF POLYBROMINATED DIPHENYL ETHERS (PBDEs) AND STRUCTURES OF DEIODINASE2017

    • Author(s)
      Kaoruko Mizukawa, Kazuya Yokota, Hideshige Takada, Matthew C. Salanga, Jared V. Goldstone, John J. Stegeman
    • Organizer
      PRIMO2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ポリ臭素化ジフェニルエーテルの魚類による脱臭素化と脱ヨウ素酵素の種差2016

    • Author(s)
      水川薫子
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟県新潟市ときメッセ
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリ臭素化時フェニルエーテルの魚類による脱臭素化能とと脱ヨウ素酵素の関係2016

    • Author(s)
      水川薫子
    • Organizer
      第25回環境化学討論会
    • Place of Presentation
      新潟県 新潟コンベンションセンター
    • Year and Date
      2016-06-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-02-16  

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