The physiological significance of the change in biomembrane fatty acids according to nutritional state
Project/Area Number |
15K16203
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Ochanomizu University |
Principal Investigator |
Ikuyo Ichi お茶の水女子大学, 基幹研究院, 講師 (50403316)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂肪酸 / 必須脂肪酸 / 脂肪滴 / リン脂質 / 多価不飽和脂肪酸 |
Outline of Final Research Achievements |
In this study, we examined that the biological significance of biomembrane fatty acids via the excess or deficiency of fatty acids. First, we focused the phospholipid fatty acids in lipid droplets of adipocytes as a model of over nutrition. We clarified that the biophysical properties of lipids themselves constituting lipid droplets contributed to the formation of large lipid droplets. Furthermore, Our results suggest that saturated fatty acid chains in phospholipid monolayers might establish the form and/or stability of large LDs. In addition, as a model of nutritional deficiency, we examined the change of fatty acid metabolism during essential fatty acid deficiency. We revealed that Elovl5 of fatty acid elongation enzyme changed the substrate specificity via phosphorylation modification and induced the synthesis of Mead acid (C20:3n-9) in essential fatty acid deficiency.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial2017
Author(s)
S. Takase, T. Matoba, S. Nakashiro, Y. Mukai, S. Inoue, K. Oi, T. Higo, S. Katsuki, M. Takemoto, N. Suematsu, K. Eshima, K. Miyata, M. Yamamoto, M. Usui, K. Sadamatsu, S. Satoh, T. Kadokami, K .Hironaga, I. Ichi, K. Todaka, J. Kishimoto, K. Egashira, K. Sunagawa
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 37
Issue: 2
Pages: 350-358
DOI
Related Report
Peer Reviewed
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[Journal Article] TTC39B Deficiency Stabilizes LXR Leading to Decreased Atherosclerosis and Hepatic Steatosis2016
Author(s)
M. Koseki, J. Hsieh, M. M. Molusky, E. Yakushiji, I. Ichi, M. Westerterp, S. Abramowicz, L. Tascau, C. B. Welch, J. Iqbal, S. Takiguchi, S. Yamashita, M. M. Hussain, D. J. Rader, and A. R. Tall
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Journal Title
Nature
Volume: 535
Issue: 7611
Pages: 303-307
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] TTC39B Deficiency Stabilizes LXR Leading to Decreased Atherosclerosis and Hepatic Steatosis2016
Author(s)
Masahiro Koseki, Joanne Hsieh1, Matthew M. Molusky, Emi Yakushiji, Ikuyo Ichi, Marit Westerterp, Sandra Abramowicz, Liana Tascau, Carrie B. Welch, Jahangir Iqbal, Shunichi Takiguchi, Shizuya Yamashita, M. Mahmood Hussain, Daniel J. Rader, and Alan R. Tall1
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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