Elucidation of a mehcanism of Diabete mellitus attributed to ectopic fat and its suppressive effect with food ingredients
| Project/Area Number |
15K16204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Yamanashi Gakuin University (2017)
University of Yamanashi (2015-2016) |
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Principal Investigator |
Hariya Natsuyo 山梨学院大学, 健康栄養学部, 准教授 (80732784)
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| Research Collaborator |
MOCHIZUKI Kazuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | インスリン抵抗性 / 食物繊維 / カロテノイド / 異所性脂肪細胞 / 抗酸化食品成分 / 糖代謝 / 脂質代謝 / 高脂肪食 / ベータカロテン / 動脈硬化 / エピゲノム因子 / 水溶性食物繊維 / 食後高血糖 |
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| Outline of Final Research Achievements |
In this study, we examined the effects of food ingredients and epigenetic factors on pathological condition improvement in each condition of diet induced insulin resistance. It is suggested that β-carotene may lead to exacerbation of the disease state. It turned out that the effect of water - soluble dietary fiber pectin improvement depending on the content of pectin in the diet and the degree of glucose tolerance in type 2 diabetes rats. Inhibition of epigenetic factor BRD4 suppressed the effect of high fructose diet, however pathological condition could be exacerbated by excessive suppression of BRD4.
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Report
(4 results)
Research Products
(1 results)
