The role of astrocyte lipid rafts in mental disorder induced by a lack of nutrition
Project/Area Number |
15K16206
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Eating habits
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 脂肪酸結合蛋白質 / FABP7 / アストロサイト / 脂質ラフト / caveolin-1 / 神経可塑性 / ヒストンアセチル化 / エピゲノム |
Outline of Final Research Achievements |
Recently, the relationship between higher brain functions and neurological disorder has been paid attention. It is reported that a lack of nutrition such as n-3 polyunsaturated fatty acids (PUFAs) induces mental disorders, but its mechanism is still unknown. In this study, we focused the fatty acid binding protein (FABP7) which is highly expressed in astrocytes and has high affinity with n-3 PUFAs. We examined whether FABP7 is involved in the functions of lipid rafts which is the main source of cellular activity in response to external stimuli. The following results have been so far obtained: 1. FABP7 controls lipid raft function through regulation of caveolin-1 expression and is involved in the response of astrocytes to the external stimuli, 2. altered production of humoral factors from FABP7-KO astrocytes induced neuroplasticity changes.
|
Report
(3 results)
Research Products
(21 results)
-
-
-
[Journal Article] Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons.2016
Author(s)
Ebrahimi M, Yamamoto Y, Sharifi K, Kida H, Kagawa Y, Yasumoto Y, Islam A, Miyazaki H, Shimamoto C, Maekawa M, Mitsushima D, Yoshikawa T, Owada Y.
-
Journal Title
Glia
Volume: 64(1)
Issue: 1
Pages: 48-62
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Inhibition of fatty acid synthase decreases expression of stemness markers in glioma stem cells.2016
Author(s)
Yasumoto Y., Miyazaki H., Vaidyan L.K., Kagawa Y., Ebrahimi M., Yamamoto Y., Ogata M., Katsuyama Y., Sadahiro H., Suzuki M., & Owada Y.
-
Journal Title
PLoS One
Volume: 11(1)
Issue: 1
Pages: 11-11
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Proteomic differential display analysis reveals decreased expression of PEA-15 and vimentin in FABP7-deficient astrocytes.2015
Author(s)
Ebrahimi, M., Sharifi, K., Islam, A., Miyazaki, H., Yasumoto, Y., Kagawa, Y., Yamamoto, Y., Kitagawa, T., Kuramitsu, Y., Nakamura, K. and Owada, Y.
-
Journal Title
J Proteom Bioinform.
Volume: 8
Issue: 01
Pages: 9-14
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1.2015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
-
Journal Title
Glia
Volume: 63
Issue: 5
Pages: 780-794
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts2015
Author(s)
Satoshi Shirao, Hiroshi Yoneda, Mizuya Shinoyama, Kazutaka Sugimoto, Hiroyasu Koizumi, Hideyuki Ishihara, Fumiaki Oka, Hirokazu Sadahiro, Sadahiro Nomura, Masami Fujii, Masakatsu Tamechika, Yoshiteru Kagawa, Yuji Owada, and Michiyasu Suzuki
-
Journal Title
Journal of Cerebral Blood Flow and Metabolism
Volume: 印刷中
Issue: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-