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Mechanism of Hypophosphatemia during refeeding syndrome

Research Project

Project/Area Number 15K16214
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionUniversity of Hyogo

Principal Investigator

TANAKA SARASA  兵庫県立大学, 環境人間学部, 助教 (90733387)

Co-Investigator(Renkei-kenkyūsha) SAKAUE Motoyoshi  兵庫県立大学, 環境人間学部, 教授 (20283913)
ITOH Mikiko  兵庫県立大学, 環境人間学部, 教授 (50314852)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsリフィーディングシンドローム / 低リン血症 / インスリン
Outline of Final Research Achievements

Refeeding syndrome (RFS) occurs following aggressive nutritional supplementation in malnourished patients. Hypophosphatemia is the hallmark of RFS and key to its prevention and treatment. However, the mechanism of RFS is unclear because of the lack of an animal model. In this study, we developed a rat RFS model as a first step to clarifying the molecular mechanism. Rats were fasted for 5 days and refeeding on a high calorie solution with or without insulin administration was started using total parenteral nutrition. Results showed that plasma phosphate levels did not decrease in rats infused with the high calorie solution alone; in contrast, insulin leaded hypophosphatemia. In addition, rats infused with the high calorie solution containing added phosphate did not present with hypophosphatemia. Thus, we developed a rat RFS model with hypophosphatemia by tube feeding and insulin administration, and demonstrated the importance of phosphate in preventing refeeding hypophosphatemia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats2018

    • Author(s)
      Kawamura H, Tanaka S, Uenami Y, Tani M, Ishitani M, Morii S, Sakaue M, Ito M
    • Journal Title

      The Journal of Medical Investigation

      Volume: 65 Issue: 1.2 Pages: 50-55

    • DOI

      10.2152/jmi.65.50

    • NAID

      130006575588

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] TPNを用いたリフィーディングシンドロームモデルラットの構築.2018

    • Author(s)
      4.河村弘美,田中更沙,谷真理子,石谷翠里,森井沙衣子,坂上元祥,伊藤美紀子
    • Organizer
      第21回日本病態栄養学会年次学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リフィーディングにおいてリンが糖代謝異常に及ぼす影響の検討2017

    • Author(s)
      河村弘美
    • Organizer
      第20回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2017-01-13
    • Related Report
      2016 Research-status Report
  • [Presentation] リフィーディングにおいてリンが急性期の糖代謝に及ぼす影響2017

    • Author(s)
      3.河村弘美,上波友理,増田円,谷真理子,石谷翠里,大枝千紘,松井麻有,田中更沙,伊藤美紀子
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リフィーディングにおける糖代謝とリン代謝の相互作用2016

    • Author(s)
      河村弘美
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] リフィーディングシンドロームにおけるリン代謝異常の検討2016

    • Author(s)
      田中更沙
    • Organizer
      第19回日本病態栄養学会年次学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of abnormal phophorus metabolism in fasting status.2015

    • Author(s)
      Sarasa Tanaka
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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