Contribution of brown fat thermogenesis to the anti-obesity effect of dietary protein and amino acid.
Project/Area Number |
15K16215
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Tenshi College |
Principal Investigator |
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Research Collaborator |
SAITO Masayuki 北海道大学, 名誉教授
SUGIE Hiroki LSI札幌クリニック, 理事長
KAMEYA Toshimitsu LSI札幌クリニック, 放射線技師
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 肥満 / エネルギー代謝 / 脂肪組織 / アミノ酸 / 褐色脂肪組織 / BCAA / エネルギー消費量 / タンパク質 |
Outline of Final Research Achievements |
To clarify a role of brown adipose tissue (BAT) in postprandial thermogenesis, energy expenditure after intake of a high-protein meal was measured in healthy human subjects. When compared with the response to a control meal, the protein-induced thermogenesis was found to be higher in subjects with high BAT activity than those with low BAT activity. These results suggest a significant role of BAT in protein-induced thermogenesis. Blood amino acid levels were compared between the high and low BAT groups.Although blood levels of all amino acids of the two groups were comparable under a thermoneutral warm condition, branched chain amino acids (BCAA) levels were decreased after 2-hr cold exposure only in the high BAT group. It is thus suggested that BCAA may be actively metabolized by BAT in humans.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans2016
Author(s)
Hibi H, Oishi S, Matsushita M, Yoneshiro T, Yamaguchi T, Usui C, Yasunaga K, Katsuragi Y, Kubota K, Tanaka S, Saito M
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Journal Title
Int J Obes
Volume: 40
Issue: 11
Pages: 1655-1661
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] <i>Kaempferia parviflora</i> Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue2015
Author(s)
Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi N, Takagaki K, Kameya T, Sugie H, Saito M.
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: 1
Pages: 79-83
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Journal Article] 青年と中高年における食生活とメンタルヘルスの関連性2015
Author(s)
福士一恵,鈴木純子,大塚吉則, 大久保岩男,清水真理,白幡亜希,松下真美,百々瀬いづみ,山口敦子,梅澤敦子,小林良子,斉藤昌之,久保ちづる, 古川直美, 峯岸夕紀子, 武蔵学,森谷絜
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Journal Title
天使大学紀要
Volume: 16(1)
Pages: 1-19
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Brown adipose tissue is involved in diet-induced thermogenesis and whole body fat utilization in healthy humans2016
Author(s)
Tanaka S, Hibi M, Oishi S, Yamaguchi T, Yasunaga K, Yoneshiro T, Matsushita M, Usui C, Kubota K and Saito M
Organizer
International Congress on Obesity
Place of Presentation
Vancouver Convention Centre, Vancouver, Canada
Year and Date
2016-05-01
Related Report
Int'l Joint Research
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