| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
We reported before that plasma erythropoietin concentration and kidney erythropoietin mRNA levels were significantly different between zinc deficiency and diet restriction. Therefore, we have examined whether zinc deficiency and diet restriction affect GATA1, GATA2, GATA3, GATA4, GATA6, Gatad1, Gatad2a, Gatad2b, HIF1a, HIF1an and HIF3a in kidney medulla and cortex.
GATA1, Gatad1, Gatad2a, Gatad2b, HIF1a and HIF1an concentrations in the kidney medulla of ZD and PF were significantly decreased compared with Control. All genes were not significantly changed in kidney cortex. These results suggest that kidney erythropoietin expression is decreased by zinc deficiency and diet restriction, and both conditions affect expression of GATA1, GATA2, GATA3, GATA4, GATA6, Gatad1, Gatad2a, Gatad2b, HIF1a, HIF1an and HIF3a in kidney medulla.
|
