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Study of hematopoietic disorder and blood pressure abnormality which occur frequency in hemodialysis patients. -Approach from zinc and iron condition-

Research Project

Project/Area Number 15K16216
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionYasuda Women's University (2017-2018)
Kyushu Women's University (2015-2016)

Principal Investigator

Konomi Aki  安田女子大学, 家政学部, 講師 (40529658)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords亜鉛 / 造血 / エリスロポエチン / 貧血 / mRNA / 造血障害
Outline of Final Research Achievements

We reported before that plasma erythropoietin concentration and kidney erythropoietin mRNA levels were significantly different between zinc deficiency and diet restriction. Therefore, we have examined whether zinc deficiency and diet restriction affect GATA1, GATA2, GATA3, GATA4, GATA6, Gatad1, Gatad2a, Gatad2b, HIF1a, HIF1an and HIF3a in kidney medulla and cortex.
GATA1, Gatad1, Gatad2a, Gatad2b, HIF1a and HIF1an concentrations in the kidney medulla of ZD and PF were significantly decreased compared with Control. All genes were not significantly changed in kidney cortex. These results suggest that kidney erythropoietin expression is decreased by zinc deficiency and diet restriction, and both conditions affect expression of GATA1, GATA2, GATA3, GATA4, GATA6, Gatad1, Gatad2a, Gatad2b, HIF1a, HIF1an and HIF3a in kidney medulla.

Academic Significance and Societal Importance of the Research Achievements

本研究は、亜鉛が造血及び血圧調節にかかわる遺伝子に及ぼす作用を精査し、これら疾患の発生機序を明らかにすることを目的として実施した。
亜鉛欠乏ないし食餌制限で生じる造血障害にGATA1、Gatad1、Gatad2a、Gatad2b、HIF1aおよびHIF1an遺伝子が影響していることを明らかにしたが、造血障害発生メカニズムの質的な差を説明するためにさらに検討が必要である。
最終的には、血液透析患者に多発する「難治性造血障害」と「血圧異常症」の新規治療法の開発につながる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Iron deficiency without anaemia is a potential cause of fatigue: meta-analyses of randomised controlled trials and cross- sectional studies2017

    • Author(s)
      Katsuhiko Yokoi, Aki Konomi
    • Journal Title

      British Journal of Nutrition

      Volume: 117(10) Pages: 1422-1431

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 鉄と亜鉛の単独もしくは同時欠乏の生体影響2015

    • Author(s)
      許斐 亜紀
    • Journal Title

      Biomedical Research on Trace Elements

      Volume: 26(3) Pages: 124-133

    • NAID

      130005113918

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The effect of zinc deficiency and diet restriction on gene expression of hypoxia-inducible factors in rat's kidney2018

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Organizer
      Experimental Biology2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 亜鉛欠乏が腎臓での低酸素誘導因子(HIF)遺伝子発現に与える影響2018

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第72回 日本栄養・食糧学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 亜鉛欠乏および食餌量制限が腎臓でのHIF遺伝子発現に与える影響2018

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第35回 日本微量栄養素学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食餌環境の違いが腎臓中HIFおよびCBP/p300遺伝子発現に与える影響2018

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第29回 日本微量元素学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The effect of zinc deficiency and diet restriction on GATA family gene expression in rat’s kidney2017

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Organizer
      Experimental Biology2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dose-effect relationship between dietary iron and hematological parameters in rats2017

    • Author(s)
      Katsuhiko Yokoi,Aki Konomi
    • Organizer
      Experimental Biology2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 亜鉛欠乏および食餌量制限時の腎臓でのGATA関連遺伝子発現量2017

    • Author(s)
      許斐 亜紀、横井 克彦
    • Organizer
      第34回 日本微量栄養素学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 貧血を伴わない鉄欠乏が脂質代謝に及ぼす影響の一考察2017

    • Author(s)
      澤田 孝子、許斐 亜紀、横井 克彦
    • Organizer
      第34回 日本微量栄養素学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 貧血のない鉄欠乏と疲労の関連2017

    • Author(s)
      横井 克彦、許斐 亜紀
    • Organizer
      第28回 日本微量元素学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食餌環境が腎臓中での造血関連遺伝子の発現に与える影響2017

    • Author(s)
      許斐 亜紀、横井 克彦
    • Organizer
      第64回 日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effect of zinc deficiency and diet restriction for erythropoietin production in rats2016

    • Author(s)
      Aki Konomi, Katsuhiko Yokoi
    • Organizer
      XVIIth International Congress of Dietetics
    • Place of Presentation
      スペイン、グラナダ
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 亜鉛欠乏が腎臓を介して造血機能に与える影響の検討2016

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第70回 日本栄養食糧学会
    • Place of Presentation
      兵庫、神戸ポートピアホテル・武庫川女子大学
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 亜鉛欠乏および食餌量低下が腎臓でのGATA1, GATA4およびGATA5遺伝子発現に及ぼす影響2016

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第33回 日本微量栄養素学会
    • Place of Presentation
      京都、京都リサーチパーク
    • Related Report
      2016 Research-status Report
  • [Presentation] Changes of expression of hematopoiesis-related gene by zinc deficiency in rats2015

    • Author(s)
      Aki KONOMI, Katsuhiko YOKOI
    • Organizer
      XIth Conference of the International Society for Trace Elements Research in Humans
    • Place of Presentation
      Sheraton Dubrovnik Rivera Hotel (Srebreno-Dubrovnik, Croatia)
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 亜鉛欠乏が造血に及ぼす影響2015

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第62回 日本栄養改善学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎臓での遺伝子発現への中等度亜鉛欠乏および食餌摂取制限の影響2015

    • Author(s)
      許斐亜紀、横井克彦
    • Organizer
      第32回 日本微量栄養素学会
    • Place of Presentation
      京都リサーチパーク(京都府京都市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Hematological changes by zinc deficiency in rats2015

    • Author(s)
      Aki KONOMI, Katsuhiko YOKOI
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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