Regulation mechanism of glucose and lipid metabolism between brain and peripheral organs by neuropeptide GALP

• Project/Area Number: 15K16217
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: University of Human Arts and Sciences
• Principal Investigator: Hirako Satoshi 人間総合科学大学, 人間科学部, 講師 (90644261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: GALP / 抗肥満 / 脂質代謝 / 糖代謝 / マウス / ガラニン様ペプチド / 肥満 / 胆汁酸 / 交感神経系

Outline of Final Research Achievements

Although anti-obesity action has also been reported, details of its mechanism of action are unknown. In this research, we clarified the following. 1. It was suggested that GALP activates the sympathetic nervous system via MC4R. 2. It was revealed that GALP affects not only fatty acid but also bile acid metabolism. 3. The effect of GALP varies depending on the administration time, and it is revealed that lipid metabolism is activated immediately after administration, but glucose metabolism is activated after 16 hours.

Research Products

• [Journal Article] Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. (2018)
  • Author(s): Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.
  • Journal Title: Cell Rep. Volume: 22 Issue: 3 Pages: 706-721
  • DOI: 10.1016/j.celrep.2017.11.102
  • NAID: 120007001417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 摂食調節ペプチドGALPによる食欲・エネルギー代謝調節機構 (2017)
  • Author(s): 平子哲史、和田亘弘、影山晴秋、竹ノ谷文子、塩田清二
  • Journal Title: 人間総合科学大学 紀要 Volume: 17 Pages: 35-38
  • Peer Reviewed
• [Journal Article] Effect of intranasal administration of galanin-like peptide (GALP) on body weight and hepatic lipids accumulation in mice with diet-induced obesity (2017)
  • Author(s): HirakoS, Wada N, Kageyama H, Takenoya F , Kim H, IizukaY, Matsumoto A, Okabe M, Shioda S.
  • Journal Title: Curr Pharm Des. Volume: 印刷中 Issue: 25
  • DOI: 10.2174/1381612823666170321095950
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Protective effects of fish oil and pioglitazone on pancreatic tissue in obese KK mice with type 2 diabetes. (2016)
  • Author(s): 1)Iizuka Y, Kim H, Izawa T, Sakurai K, Hirako S, Wada M, Matsumoto A.
  • Journal Title: Prostaglandins Leukot Essent Fatty Acids. Volume: 115 Pages: 53-59
  • DOI: 10.1016/j.plefa.2016.10.007
  • NAID: 120006378316
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bihavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8. (2016)
  • Author(s): WADA N, YAMANAKA S, SHIOBATO J, RAKWAL R, HIRAKO S, IIZUKA Y, KIM H, MATSUMOTO A, KIMURA A, TAKENOYA F, YASUNAGA G, SHIODA S
  • Journal Title: Genom Data Volume: 10 Pages: 38-50
  • DOI: 10.1016/j.gdata.2016.09.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice. (2016)
  • Author(s): KAGEYAMA H, SHIBA K, HIRAKO S, WADA N, YAMANAKA S, NOGI Y, TAKENOYA F, NONAKA N, HIRAKO S, INOUE S, SHIODA S
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 28200-28200
  • DOI: 10.1038/srep28200
  • Peer Reviewed / Open Access
• [Journal Article] Fish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve glucose and lipid metabolic dysfuntions with different ways in diabetic KK mice. (2016)
  • Author(s): Nakasatomi M, Kim H, Arai T, Hirako S, Shioda S, Iizuka Y, Sakurai K, Matsumoto A
  • Journal Title: Obes Res Clin Pract Volume: Epub ahead of print Issue: 1 Pages: 29-38
  • DOI: 10.1016/j.orcp.2016.03.012
  • NAID: 120006470025
  • Peer Reviewed
• [Journal Article] Autonomic nervous system-mediated effects of GALP on energy metabolism (2016)
  • Author(s): HIRAKO S, WADA N, KAGEYAMA H, TAKENOYA F, INOUE S, SHIODA S
  • Journal Title: Folia Pharmacologica Japonica Volume: 148 Issue: 1 Pages: 23-27
  • DOI: 10.1254/fpj.148.23
  • NAID: 130005164793
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Open Access
• [Journal Article] Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue. (2016)
  • Author(s): HirakoS, Wada N, Kageyama H, Takenoya F , Izumida Y, Kim H, IizukaY, Matsumoto A, Okabe M, Kimura A, Suzuki M, Yamanaka S, Shioda S.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 1-9
  • DOI: 10.1038/srep21481
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hepatic lipid accumulation is ameliorated in obese KK mice by dietary sei whale oil. (2016)
  • Author(s): Hirako S, Suzuki M, Kim H, Iizuka I, Matsumoto A, Wada N, Okabe M, Takenoya F, Yasunaga G, Yamanaka S, Miyazaki A, Shioda S.
  • Journal Title: Fish Sci. Volume: 82 Issue: 3 Pages: 509-517
  • DOI: 10.1007/s12562-016-0971-2
  • NAID: 40020863321
  • Peer Reviewed
• [Journal Article] Fish oil prevents excessive accumulation of subcutaneous fat caused by an adverse effect of pioglitazone treatment and positively changes adipocytes in KK mice. (2016)
  • Author(s): Iizuka Y, Kim H, Nakasatomi M, Izawa T, Hirako S, Matsumoto A.
  • Journal Title: Toxicol Rep. Volume: 3 Pages: 4-14
  • DOI: 10.1016/j.toxrep.2015.11.003
  • NAID: 120006306625
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice. (2015)
  • Author(s): Hirako S, Wakayama Y, Kim H, Iizuka Y, Matsumoto A, Wada N, Kimura A, Okabe M, Sakagami J, Suzuki M, Takenoya F, Shioda S
  • Journal Title: Obes Res Clin Pract Volume: Epub ahead of print Issue: 6 Pages: 38-50
  • DOI: 10.1016/j.orcp.2015.12.001
  • Peer Reviewed / Open Access
• [Journal Article] AQP7 Up-Regulation in the Skeletal Muscles of Mice with Diet Induced Obesity. (2015)
  • Author(s): Wakayama Y, Hirako S, Jimi T, Shioda S.
  • Journal Title: Cell Sci Ther. Volume: 6 Issue: 02 Pages: 1-5
  • DOI: 10.4172/2157-7013.1000205
  • Peer Reviewed / Open Access
• [Presentation] Galanin-like peptide (GALP) alters lipid metabolism and improves obesity. (2017)
  • Author(s): Hirako S, Wada N, Kageyama H, Takaenoya F, Shioda S.
  • Organizer: 58th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] ガラニン様ペプチド(GALP)が脂肪酸・コレステロール代謝に与える影響 (2017)
  • Author(s): 平子哲史、和田亘弘、影山晴秋、竹ノ谷文子、塩田清二.
  • Organizer: 第71会日本栄養・食糧学会大会
• [Presentation] Effect of intranasal GALP on obesity and hepatic lipid metabolism in obese mice (2016)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S
  • Organizer: 12th Asian Congress of Nutrition.
  • Place of Presentation: 横浜
  • Year and Date: 2016-05-14
  • Int'l Joint Research
• [Presentation] ガラニン様ペプチド(GALP)による末梢組織でのエネルギー代謝調節作用およびそのメカニズムの解明. (2016)
  • Author(s): 平子哲史、和田亘弘、影山晴秋、竹ノ谷文子、塩田清二.
  • Organizer: 第70会日本栄養・食糧学会大会
  • Place of Presentation: 武庫川女子大学
  • Year and Date: 2016-05-13
• [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver. (2016)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
  • Organizer: 13th International Congress on Obesity
  • Place of Presentation: バンクーバー
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] 神経ペプチドGALPによる末梢組織での脂質代謝調節作用 (2015)
  • Author(s): 平子哲史・竹ノ谷文子・影山晴秋・和田亘弘・塩田清二
  • Organizer: 第37回日本臨床栄養学会総会・第36回日本臨床栄養協会総会 第13回大連合大会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-02
• [Presentation] GALPによる自律神経系を介した脂質代謝調節機構 (2015)
  • Author(s): 平子哲史・竹ノ谷文子・和田亘弘・塩田清二
  • Organizer: 第12回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15