| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Beige and brown adipocytes, which constitute BAT, have many mitochondria containing uncoupling protein 1 (UCP1). UCP1 uncouples the respiratory chain, allowing for fast substrate oxidation, and functions as a radiator for thermogenesis to maintain body temperature. Activation of thermogenic adipocyte has been considered an attractive target for weight loss and treatment of metabolic disease. A PPARγ agonist, rosiglitazone, promotes thermogenic adipocyte differentiation in mouse WAT. It has been reported that α-tocopherol influence PPARγ expression and the target genes expression. In this study, we investigated that the effect of α-tocopherol on beige adipocyte differentiation. The results of our study suggest that α-tocopherol promotes thermogenic adipocyte differentiation. We also suggest that PGC-1α upregulation by α-tocopherol contribute thermogenic adipocyte differentiation.
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