Effects of sialyl-lactose on memory in rodents

• Project/Area Number: 15K16221
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Nagoya Keizai University (2017); Chubu University (2015-2016)
• Principal Investigator: Yamada Takashi 名古屋経済大学, 人間生活科学部管理栄養学科, 准教授 (50531860)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: シアリルラクトース / 栄養学 / 記憶学習

Outline of Final Research Achievements

In this study, we examined the effect of sialyl-lactose on memory and elucidated the mechanism in rodents.
Sialyl-lactose fed 24 months-old rats and senescence accelerated prone mice were decreased serum cholesterol level and increased brain dopamine, serotonin nerve growth factor levels. In addition, memory related behaviors were improved in sialyl-lactose fed senescence accelerated prone mice. These results suggested sialyl-lactose has the maintenance effect on memory in old age.