Effects of vitamin B1 deficiency on skeletal muscle mass and function in rats

• Project/Area Number: 15K16223
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kawasaki University of Medical Welfare (2017); Okayama Prefectural University (2015-2016)
• Principal Investigator: KANZAKI KEITA 川崎医療福祉大学, 医療技術学部, 講師 (30637286)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 骨格筋 / 筋萎縮 / 筋疲労 / ビタミン / 欠乏 / 疲労耐性 / グリコーゲン / 乳酸 / ビタミンB1 / 筋量 / 筋力 / 筋力低下 / 欠乏症

Outline of Final Research Achievements

The aim of this study was to determine the effects of vitamin B1 deficiency on skeletal muscle mass and function. Vitamin B1 deficiency was induced in the rats by feeding them low vitamin B1 diets. We here found that a few weeks of vitamin B1 deficiency 1) could lead to a loss of fast-twitch muscles, 2) is not associated with a decrease in specific force production, and 3) results in a decline in muscle fatigue resistance.

Research Products

• [Journal Article] Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle (2015)
  • Author(s): Watanabe, D., Kanzaki, K., Kuratani, M., Matsunaga, S., Yanaka, N. and Wada, M.
  • Journal Title: Journal of Muscle Reearch and Cell Motility Volume: 印刷中 Issue: 3 Pages: 275-286
  • DOI: 10.1007/s10974-015-9409-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Muscle dysfunction associated with adjuvant induced-arthritis is prevented by antioxidant treatment (2015)
  • Author(s): Yamada, T., Abe, M., Lee, J., Tatebayashi, D., Himori, K., Kanzaki, K., Wada, M., Bruton, JD., Westerblad, H. and Lanner, JT.
  • Journal Title: Skeletal Muscle Volume: 5 Issue: 1 Pages: 20-20
  • DOI: 10.1186/s13395-015-0045-7
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] カルパインの阻害が伸張性収縮に伴うカルシウム調節タンパク質の分解に及ぼす影響 (2015)
  • Author(s): 神崎圭太，渡邊大輝，和田正信．
  • Organizer: 第1回日本筋学会学術集会
  • Place of Presentation: 小平市
  • Year and Date: 2015-08-08
• [Presentation] 抗酸化剤の投与はアジュバント関節炎ラットにおける筋機能低下を防止する (2015)
  • Author(s): 山田崇史、阿部真佐美、李宰植、舘林大介、檜森弘一、神崎圭太、和田正信、JOSEPH D. BRUTON、HAKAN WESTERBLAD、JOHANNA T. LANNER．
  • Organizer: 第1回日本筋学会学術集会
  • Place of Presentation: 小平市
  • Year and Date: 2015-08-08
• [Presentation] Soy protein diet prevents eccentric contraction-induced calpain activation and force depression. (2015)
  • Author(s): Keita Kanzaki, Daiki Watanabe, Yuya Ishii, Katsutoshi Hirano, Masanobu Wada.
  • Organizer: 12th Asian congress of nutrition
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2015-05-14
  • Int'l Joint Research