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Realization of an anti-obesity activity evaluation and analysis system aimed at introduction of new indices

Research Project

Project/Area Number 15K16233
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionTeikyo University

Principal Investigator

Unno Yuka  帝京大学, 医学部, 助教 (30433212)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肥満 / 脂肪細胞 / 脂質 / 機能性食品 / スクリーニング / 培養細胞 / 探索 / ケミカルバイオロジー / 分化機構
Outline of Final Research Achievements

Our research aims to establish a unified standard of measuring anti-obesity activity by refining a cultured cell evaluation system into a system that can predict elimination of obesity at the individual level.
In this research project, we are screening for lipophilic ingredients that may have anti-obesity effects from Krill oil, which has long been used as an oil to protect the health of people who consume a meat-centered diet with few vegetables, such as those living in Antarctica. We have successfully discovered several functional ingredients. The underlying mechanism of action of the components found is still under analysis using cultured cells.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Virulence characteristics of Acinetobacter baumannii clinical isolates vary with the expression levels of omps2017

    • Author(s)
      Sato Y, Unno Y, Kawakami S, Ubagai T, Ono Y.
    • Journal Title

      J. Med. Microbiol.

      Volume: 66 Issue: 2 Pages: 203

    • DOI

      10.1099/jmm.0.000394

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] LPSは脂肪細胞とマクロファージの共培養系でMIP2産生を促進する2017

    • Author(s)
      海野雄加、佐藤義則、永川茂、鴨志田剛、西田智、上田たかね、祖母井庸之、斧康雄
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] クリルオイル由来脂溶性成分による抗肥満効果の解明2017

    • Author(s)
      海野雄加、山本宙奈、高槻修人、矢澤一良、脇本敏幸、斧康雄
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Immunonutritionとしての各種不飽和脂肪酸の好中球機能に及ぼす影響2017

    • Author(s)
      海野雄加、永川茂、佐藤義則、鴨志田剛、西田智、上田たかね、祖母井庸之、斧康雄
    • Organizer
      第91回日本感染症学会総会・学術講演会 第65回日本化学療法学会学術集会 合同学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2016 Annual Research Report
  • [Presentation] The function of 8-nitroguanosine as a unique signal molecule during differentiation of 3T3-L1 preadipocytes2016

    • Author(s)
      Unno Y., Akuta T., Ida T., Sawa T., Ono Y., Akaike T.
    • Organizer
      9th International NO conference
    • Place of Presentation
      仙台国際センター (宮城・仙台)
    • Year and Date
      2016-05-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The function of 8-nitroguanosine as a unique signal molecule via induction of HO-1 expression in 3T3-L1 adipocytes2016

    • Author(s)
      Unno Y, Akuta T, Ida T, Sawa T, Ono Y, Akaike T,
    • Organizer
      The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan / The 9th Internatinal Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Sendai International Center(仙台)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アディポカイン発現に対する多剤耐性Acinetobacter baumannii由来リポ多糖の影響2016

    • Author(s)
      海野雄加, 佐藤義則, 西田智, 中野竜一, 永川茂, 上田たかね, 鴨志田剛, 祖母井庸之, 斧康雄
    • Organizer
      日本感染症学会 第90回総会
    • Place of Presentation
      仙台国際センター (宮城・仙台)
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] アディポカイン発現に対する多剤耐性Acinetobacter baumannii由来リポ多糖の影響2016

    • Author(s)
      海野雄加、佐藤義則、西田智、中野竜一、中野章代、永川茂、上田たかね、鴨志田剛、祖母井庸之、斧康雄
    • Organizer
      第90回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脂肪細胞のアディポカイン発現に対するグラム陰性桿菌由来リポ多糖の影響2016

    • Author(s)
      海野雄加, 佐藤義則, 西田智, 永川茂, 鴨志田剛, 上田たかね, 祖母井庸之, 斧康雄
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター (大阪・大阪)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Krill oilは3T3-L1前駆脂肪細胞に微小な脂肪滴を形成する2016

    • Author(s)
      海野雄加、脇本敏幸、矢澤一良、斧康雄
    • Organizer
      日本肥満学会アディポサイエンス・シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2016 Annual Research Report
  • [Presentation] アディポカイン発現に対する多剤耐性Acinetobacter baumannii由来リポ多糖 の影響2015

    • Author(s)
      海野雄加, 佐藤義則, 西田智, 中野竜一, 中野章代, 永川茂, 上田たかね, 鴨志田剛, 祖母井庸之, 斧康雄
    • Organizer
      第64回日本感染症学会東日本地方会学術集会・第62回日本化学療法学会東日本支部総会合同学会
    • Place of Presentation
      ロイトン札幌 (北海道・札幌)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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