A study of metabolic dynamics of purine derived from daily diet for prevention of hyperuricemia
Project/Area Number |
15K16238
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Teikyo University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 尿酸値 / プリン体 / 旨み / 食品 / 一斉分析 / HPLC / 腸管吸収 / 代謝 / Caco-2細胞 / フルクトース / 有機酸 / 痛風 |
Outline of Final Research Achievements |
Purines in foods are often evaluated as the total purine amount (in terms of uric acid), but the purine form exists in various ways, such as nucleic acids, nucleotides, nucleosides, purine bases. These metabolic processes to uric acid, intestinal absorption, and/or more reuse efficiency as energy should be considered also not uniform. Thus, both the amount of total purines in the food and the what types of purine are included are important that should be taken into consideration regarding nutritional therapy for gout or hyperuricemia with particular respect for the restriction of dietary purines. In this study, we determined 19 types of purine(nucleotides ,nucleosides and purine bases) content of daily foods. Furthermore, I aimed to evaluate the effects of purines and other ingredients contained in food on intestinal absorption, and / or extra- and intracellular purine metabolism in cultured cells.
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Report
(4 results)
Research Products
(39 results)
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[Presentation] 豆類に含まれるプリン体量の測定2016
Author(s)
樋口 華捺, 高柳 ふくえ, 神代 くるみ, 福内 友子, 山岡 法子, 安田 誠, 馬渡 健一, 中込 和哉, 金子 希代子
Organizer
日本薬学会第136年会
Place of Presentation
横浜市
Year and Date
2016-03-26
Related Report
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[Presentation] LC-MSを用いた高プリン体食負荷におけるマウス血しょう、尿および臓器中のプリン・ピリミジン塩基の体内動態の評価2016
Author(s)
河野 眞土加, 早川 洸, 秋元 南, 東 奈実, 酒井 紫帆, 富岡 直子, 福内 友子, 山岡 法子, 安田 誠, 馬渡 健一, 中込 和哉, 細山田 真, 金子 希代子
Organizer
日本薬学会第136年会
Place of Presentation
横浜市
Year and Date
2016-03-26
Related Report
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