| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Life-style disease including NASH has been associated with hyperglycemis state and excessive intake of food derived advanced glycation end-products (AGEs). To diagnose NASH, we had already found that Toxic AGEs (TAGE) to be useful for disease marker, but the TAGE-modified target protein has not be identified yet. In this study, we identified TAGE modified caspase-3 which has a possibility for the diagnosis of NASH. Furthermore, we screened food ingredients that have an effect of suppressing the TAGE modification of caspase-3, and found several substances that can be applied to lifestyle disease prevention factors.
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