| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In this research, we performed to fabricate a compact and portable device that detect circulating tumor cells (CTC) and analyze nucleic acids using ultra-sensitive biosensor based-on the principle of field effect transistors (FETs). Model breast cancer epithelial cells were immobilized on the sensor which the probe molecules were immobilized, and then electrical measurement was performed. Because cancer cells have a negative charge derived from sialic acids, we succeeded in electrically discriminating cancer cells and epithelial cells according to the difference in the amount of sialic acid expression on cell membrane. Furthermore, we tried to develop an early diagnosis device for cancer by analyzing the nucleic acid.
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