Establishment of safe and effective photodynamic therapy by controlling of type of cell death
| Project/Area Number |
15K16322
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
Honda Norihiro 大阪大学, 工学研究科, 特任助教(常勤) (60710100)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 光線力学療法 / 一重項酸素 / 計算機シミュレーション / 壊死 / アポトーシス / 一重項酸素生成量子収率 / 細胞死様式 |
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| Outline of Final Research Achievements |
The determination of appropriate condition for inducing tumor selective and a proper cell death modality in photodynamic therapy (PDT), which is one of the less-invasive tumor treatment method, is very important for enduring safety and effecacy of PDT.The cell death modality depends on the condition of PDT. And, PDT effect depends on the amount of reactive oxygen species, especially singlet oxygen.Then in this study, the relationship between the type of cell death and cumulated generated singlet oxygen in PDT was investigated by computer simulation.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] 緑色または赤色発光ダイオードを用いた光線力学治療のシミュレーションによる比較2016
Author(s)
間久直, 本多典広, 福原秀雄, 井上啓史, 執印太郎, 倉林睦, 降幡睦夫, 津田雅之, 石井琢也, 山内視嗣, 村上清隆, 井上克司, 石塚昌宏, 田中徹, 粟津邦男
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Journal Title
レーザー研究
Volume: 44
Pages: 187-192
Related Report
Peer Reviewed
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[Presentation] Usage of reprication-deficient viral particle for photodynamic therapy against prostate cancer allows high cytotoxicity through different pathways2016
Author(s)
Norihiro Honda, Mizuho Inai, Tasuku Furuyama, Young Soon Hong, Hisanao Hazama, Hiroyuki Nakamura, Hidehiro Yasuda, Tomoyuki Nishikawa, Yasufumi Kaneda, Kunio Awazu
Organizer
Photodynamic Therapy and Photodiagnosis update
Place of Presentation
The campus of the National School of Chemical Engineering (ENSIC), Nancy, France
Related Report
Int'l Joint Research
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