| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To elucidate the mechanisms of cardiovascular diseases induced by mechanical stress, we developed in vivo imaging technique to assess morphological changes and calcium dynamics simultaneously in the stressed heart. Combined with in vivo functional analysis and micro-manipulation technique of isolated cardiomyocyte, we revealed that a mechano-sensitive channel plays a crucial role in the contractility augmentation of the heart in response to acute mechanical load. Using in vivo imaging technique, we are currently evaluating the structural deformation and calcium dynamics in response to acute mechanical load to uncover the role of the mechano-sensitive channel.
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