Medical imaging of pancreatic tumors with nanocage-based targeted contrast agent
Project/Area Number |
15K16333
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Kyushu University |
Principal Investigator |
KAWANO Takahito 九州大学, 先端医療イノベーションセンター, 特任助教 (90526831)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | MRI / 造影剤 / DDS / 画像診断システム / ナノ材料 / 分子イメージング / ナノカプセル |
Outline of Final Research Achievements |
Contrast agents with greater specificity and sensitivity are required for the diagnosis of pancreatic cancers by magnetic resonance imaging (MRI). In this study, small heat shock protein 16.5 (Hsp16.5)-based nanocages conjugated to gadolinium(III)-chelated contrast agents and iRGD peptides (which target neuropilin-1 expressed on pancreatic cancer cells) were developed. MRI data showed that larger nanocages had higher T1 relaxivity than smaller nanocages. Molecular MRI with protein nanocages was enabled to detect neuropilin-1-positive cells and to produce strong signal enhancement of spontaneous pancreatic tumors in engineered mouse models. Novel iRGD-modified nanocages displayed potential as a specific and sensitive MRI contrast agent for the diagnosis of pancreatic tumors for clinical translation.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent.2018
Author(s)
Kawano T, Murata M, Kang JH, Piao JS, Narahara S, Hyodo F, Hamano N, Guo J, Oguri S, Ohuchida K, Hashizume M
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Journal Title
Biomaterials
Volume: 152
Pages: 37-46
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis2017
Author(s)
Nakata R, Hyodo F, Murata M, Eto H, Nakaji T, Kawano T, Narahara S, Yasukawa K, Akahoshi T, Tomikawa M, Hashizume M
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 17170-17170
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Noninvasive mapping of the redox status of dimethylnitrosamine-induced hepatic fibrosis using in vivo dynamic nuclear polarization-magnetic resonance imaging2016
Author(s)
Kawano T, Murata M, Hyodo F, Eto H, Kosem N, Nakata R, Hamano N, Piao JS, Narahara S, Akahoshi T, Hashizume M
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Journal Title
Scientific Reports
Volume: -
Issue: 1
Pages: 32604-32604
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2)2016
Author(s)
Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., and Kang, J.H.
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Journal Title
Amino Acids
Volume: 48
Issue: 12
Pages: 2875-2880
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Protein NanoCages Conjugated Magnetic Resonance Contrast Agents with High Relaxivity Properties2017
Author(s)
Takahito Kawano, Masaharu Murata, Jeong-Hun Kang, Jing Shu Piao, Sayoko Narahara, Fuminori Hyodo, Nobuhito Hamano, Jie Guo, Susumu Oguri, Kenoki Ohuchida, Makoto Hashizume
Organizer
Biomaterials International 2018
Related Report
Int'l Joint Research
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