Creation of multifunctional protein film for the treatment of inflammatory diseases
| Project/Area Number |
15K16334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
YAMAZOE HIRONORI 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (00402793)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | タンパク質 / 活性酸素 / 炎症性疾患 / SOD / 抗体 / アルブミン / フィルム |
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| Outline of Final Research Achievements |
In this study, protein film was constructed by combining three types of protein with different functions, including albumin, the antibody, and superoxide dismutase (SOD). The constructed protein microfilm successfully captured the reactive oxygen species (ROS)-secreting cells using the incorporated antibody, and 70 % of ROS, secreted from the captured cells, was eliminated by SOD in the microfilm. This protein microfilm is thought to be useful for the treatment of inflammatory diseases.
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Report
(3 results)
Research Products
(10 results)
