| Project/Area Number |
15K16346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 放射線障害 / リハビリテーション / 皮膚 / 超音波療法 / リンパ管 |
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| Outline of Final Research Achievements |
This study was designed to evaluate rehabilitation (therapeutic ultrasound (TUS)) in improvement of radiation-induced skin damages, restriction of joint mobility and reduction of lymphatic vessels, using our original rat model with x-ray irradiated hind limb. Eighteen adult male rats were divided into control (Con-G), 30 Gy x-ray irradiation (30 Gy-G), and 30 Gy x-ray irradiation with TUS treatment group (US-G). In our results, radiation-induced disorders were significantly severe from 14 days after x-ray irradiation, and TUS significantly improved the skin damages 28 days after x-ray irradiation and reduced the early restriction of range of motion. The number of lymphatic vessels tended to increase in the US-G, compared with the 30 Gy-G. The present findings indicate the possibility of TUS as an adjuvant treatment for radiation-induced skin disorder, though further examinations for the morphological and molecular changes of the x-ray irradiated skin mediated by TUS are required.
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