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Gaze feedback system for retinal prostheses

Research Project

Project/Area Number 15K16353
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionOsaka University

Principal Investigator

Hiroyuki Kanda  大阪大学, 医学系研究科, 助教 (50570248)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords人工網膜 / 眼球運動 / 視線解析 / 視線検出方法 / 視線計測 / 電気刺激 / 人工臓器 / 人工視覚 / 埋込型医療機器 / ブレインマシンインターフェース / 視覚再生
Outline of Final Research Achievements

Retinal prostheses usually use an external camera, which fixed on a head-mounted device. Therefore, it is impossible to change the visual field of prosthetic vision by eye movement. To bring the prosthetic vision closer to natural vision, we proposed gaze feedback system for prosthetic vision. First, we demonstrated the efficacy of the gaze feedback system for improving eye-hand coordination. Then, we developed a prototype system of retinal prosthesis with a gaze feedback system. However, several issues of the prototype were revealed by our study. The main issues were long processing time and heavy device weight. To overcome these issues, we proposed a new eye-tracking method that estimates direction of gaze using stimulus artifacts generated by a retinal prosthesis. To confirm its feasibility, we evaluated the accuracy of the eye-tracking method using animal models. These findings from this study demonstrated that gaze direction was able to be estimated using the proposed method.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (50 results)

All 2018 2017 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (36 results) (of which Int'l Joint Research: 18 results,  Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A Sinusoidal Electrical Pulse Is More Efficient to Evoke Retinal Excitation than a Rectangular Electrical Pulse for Retinal Prostheses2018

    • Author(s)
      4.Nakano Y, Terasawa Y, Kanda H, Tashiro H, Osawa K, Miyoshi T, Sawai H, Fujikado T
    • Journal Title

      Sensors and Materials

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of triangular and sawtooth pulses in a retinal prosthesis with suprachoroidal-transretinal stimulation (STS)2018

    • Author(s)
      5.Nakano Y, Terasawa Y, Kanda H, Osawa K, Miyoshi T, Sawai H, Fujikado T,
    • Journal Title

      apanese Journal of Visual Science

      Volume: 印刷中

    • NAID

      130006943253

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between retinal damage and current intensity in a pre-clinical suprachoroidal-transretinal stimulation model using a laser-formed microporous electrode2017

    • Author(s)
      Kanda Hiroyuki、Nakano Yukari、Terasawa Yasuo、Morimoto Takeshi、Fujikado Takashi
    • Journal Title

      Journal of Neural Engineering

      Volume: 14 Issue: 5 Pages: 056013-056013

    • DOI

      10.1088/1741-2552/aa7d5c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Automated measurements of human cone photoreceptor density in healthy and degenerative retina by region-based segmentation2017

    • Author(s)
      Miyagawa Suguru、Fukuyama Hisashi、Hirota Masakazu、Yamaguchi Tatsuo、Kitamura Kazuo、Endo Takao、Kanda Hiroyuki、Morimoto Takeshi、Fujikado Takashi
    • Journal Title

      Clin Ophthalmol

      Volume: 11 Pages: 781

    • DOI

      10.2147/opth.s133070

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals.2016

    • Author(s)
      LohmanTK, Kanda H, Morimoto T, Endo T, MiyoshiT, Nishida K, Kamei M, Walter P, Fujikado T
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 254 Issue: 4 Pages: 661-673

    • DOI

      10.1007/s00417-015-3104-1

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] False reaching movements in localization test and effect of auditory feedback in simulated ultra-low vision subjects and patients with retinitis pigmentosa2016

    • Author(s)
      Endo T, Kanda H, Hirota M, Morimoto T, Nishida K, Fujikado T.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 254 Issue: 5 Pages: 947

    • DOI

      10.1007/s00417-015-3253-2

    • URL

      https://pure.teikyo.jp/en/publications/cbf3ce2b-119c-46a1-8a8b-a90a27287674

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 独立成分分析を用いた4種類の刺激に対する網膜内因性信号の検討2016

    • Author(s)
      三橋俊文広原陽子神田寛行, 大川賀孝, 三好智満, 森本壮, 不二門尚
    • Journal Title

      視覚の科学

      Volume: 37(1) Pages: 7-17

    • NAID

      130006943344

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia2016

    • Author(s)
      Hirota M, Kanda H, Endo T, Lohmann TK, Miyoshi T, Morimoto T, Fujikado T.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 60 Issue: 4 Pages: 326

    • DOI

      10.1007/s10384-016-0444-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] One-year outcome of 49-channel suprachoroidal–transretinal stimulation prosthesis in patients with advanced retinitis pigmentosa2016

    • Author(s)
      Fujikado T, Kamei M, Sakaguchi H, Kanda H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Terasawa Y, Oosawa K, Ozawa M, Nishida K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 57 Issue: 14 Pages: 6147

    • DOI

      10.1167/iovs.16-20367

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 人工網膜-最近の動向2015

    • Author(s)
      神田寛行、不二門 尚
    • Journal Title

      光技術コンタクト

      Volume: 625 Pages: 11-17

    • Related Report
      2015 Research-status Report
  • [Journal Article] 人工網膜-よみがえる光感覚-2015

    • Author(s)
      神田寛行、不二門 尚
    • Journal Title

      電子情報通信学会誌

      Volume: 98 Pages: 266-271

    • Related Report
      2015 Research-status Report
  • [Journal Article] 【電気信号を用いた神経機能再建】人工網膜(suprachoroidal-transretinal stimulation:STS)2015

    • Author(s)
      神田寛行、不二門 尚
    • Journal Title

      脳21

      Volume: 18 Pages: 84-88

    • Related Report
      2015 Research-status Report
  • [Presentation] Novel eye-tracking method for retinal prostheses.2018

    • Author(s)
      Hiroyuki Kanda
    • Organizer
      The 1st International Symposium on Systemus Intelligence Division
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel eye-tracking method for retinal prostheses.2017

    • Author(s)
      Kanda H, Satonaka S, Morimoto T, Miyoshi T, Fujikado T
    • Organizer
      ARVO2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工網膜の視機能評価を目的とした歩行テストの開発2017

    • Author(s)
      神田 寛行, 広田 雅和, 遠藤 高生, 森本 壮, 不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a Second-Generation Device for Suprachoroidal-Transretinal Stimulation2017

    • Author(s)
      Kanda H, Kamei M, Sakaguchi H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Miyoshi T, Terasawa Y, Osawa K, Ozawa M, Fujikado T
    • Organizer
      39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Temporal ptterns of single-unit responses from on- and off-cells in the lateral geniculate nucleus elicited by suprachoroidal-transretinal stimulation2017

    • Author(s)
      Hiroyuki Kanda, T Miyoshi , T Morimoto, T Fujikado
    • Organizer
      Artificial Vision 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of reaching movement and mobility with a prosthetic vision simulator.2017

    • Author(s)
      Kenta Hozumi, T Endo, M Hirota, H Kanda, T Morimoto, K Nishida, T Fujikado
    • Organizer
      Artificial Vision 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外部カメラ型人工網膜シミュレータにおける視線フィードバック機能の効果2016

    • Author(s)
      穂積 健太、遠藤 高生、広田 雅和、神田 寛行、森本 壮、不二門 尚、西田幸二
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of wide-field STS retinal prosthesis.2016

    • Author(s)
      Kanda H
    • Organizer
      The 6th MEI3 center International Symposium
    • Place of Presentation
      大阪市
    • Year and Date
      2016-01-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 視細胞変性眼における傍中心窩錐体密度とコントラスト感覚の関係2016

    • Author(s)
      広田雅和, 神田寛行, 遠藤高生, 宮川雄, 三好 智満, 森本 壮, 不二門 尚
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 2枚電極脈絡膜上-経網膜電気刺激(STS)型人工網膜の中型動物への埋植述と生体適合性2016

    • Author(s)
      森本壮, 神田 寛行, 三好 智満, 遠藤 高生, Tibor KLohmann, 西田 幸二, 不二門 尚
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 49極STS型人工網膜の慢性臨床研究の結果2016

    • Author(s)
      不二門 尚, 瓶井 資弘, 貴島晴彦, 森本壮, 神田寛行, 広田 雅和, 坂口裕和, 西田 健太郎, 遠藤 高生, 圓尾 知之, 小澤 素生, 大澤 孝治, 西田 幸二
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 外側膝状体単一ユニット活動による人工網膜多極電極の機能評価2016

    • Author(s)
      神田寛行, 森本壮, 三好 智満, 不二門尚
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 外部カメラ型人工網膜シミュレータにおける視線フィードバック機能の効果2016

    • Author(s)
      穂積健太, 遠藤高生, 広田雅和, 神田寛行, 森本壮, 不二門尚, 西田幸二
    • Organizer
      第120回日本眼科学会総会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] Improvement of reaching movement in subjects with retinal implantsimulator with gaze feedback system.2016

    • Author(s)
      Hozumi Kenta, Endo Takao, HirotaMasakazu, KandaHiroyuki, Morimoto Takeshi, Fujikado Takashi, Nishida Kohji
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Accuracy of reaching by localization tests in patient with suprachoroidal-transretinal stimulation(STS)retinal prosthesis.2016

    • Author(s)
      EndoTakao, Fujikado Takashi, Hirota Masakazu, Kanda Hiroyuki, Morimoto Takeshi, Nishida Kohji
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the spatial resolution of electrode arrays for suprachoroidal retinal prosthesis by recording single-unit activities in the lateral geniculate nucleu2016

    • Author(s)
      Kanda Hiroyuki, Miyoshi Tomomitsu, MorimotoTakeshi, FujikdaoTakashi
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical feasibility of a wide-field dual-array suprachoroidal;transretinal stimulation (STS) prosthesis in middle-sized animals2016

    • Author(s)
      Morimoto Takeshi, Kanda Hiroyuki, EndoTakao, LohmannTK, MiyoshiTomomitsu, Kishima Haruhiko, Nishida Kohji, Fujikado Takashi
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Significant Correlation between Contrast Sensitivity and Parafoveal Cone Density in Normal Eyes and Eyes with Retinal Degeneration2016

    • Author(s)
      Hirota Masakazu, Kanda Hiroyuki, Endo Takao, Miyagawa Suguru, Miyoshi Tomomitsu, Morimoto Takeshi, Fujikado Takashi
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] One-Year Outcomes of 49-Channel Suprachoroidal-Transretinal Stimulation(STS) Retinal Prosthesis in Patients with Adcanced Retinitis Pigmentosa.2016

    • Author(s)
      Fujikado Takashi, Kamei M, Kishima H, Morimoto T, KandaHiroyuki, Sakaguchi H, Nishida K, Endo T, Osawa K, Ozawa M
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 外部固視標を用いたステップ刺激に対する調節応答の評価2016

    • Author(s)
      神田寛行, 永谷広行, 広田雅和, 不二門 尚
    • Organizer
      第72回日本弱視斜視学会/第41回日本小児眼科学会総会(合同学会)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] ネコ外側膝状体ニューロン単一ユニット記録による人工網膜用刺激電極の評価2016

    • Author(s)
      神田寛行, 三好智満, 森本壮, 不二門尚
    • Organizer
      視覚科学フォーラム第20回研究会
    • Place of Presentation
      大阪CiNet
    • Related Report
      2016 Research-status Report
  • [Presentation] 脈絡膜上-経網膜方式人工視覚システムの刺激効率に及ぼす刺激波形形状の影響2016

    • Author(s)
      中野由香梨, 寺澤 靖雄, 神田 寛行, 大澤 孝治, 三好 智満, 澤井 元
    • Organizer
      第52回日本眼光学学会総会
    • Place of Presentation
      東京ソラシティカンファレンスセンター
    • Related Report
      2016 Research-status Report
  • [Presentation] Surgical Feasibility of a Wide-Field Dual-Array Suprachoroidal-Transretinal Stimulation(STS) Prosthesis in Middle-Sized Animals.2016

    • Author(s)
      Morimoto Takeshi, Kanda, Hiroyuki, Endo Takao, LohmannTibor Karl, Miyoshi Tomomitsu, Nishida Kohji, Fujikado Takashi
    • Organizer
      9th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
    • Place of Presentation
      USA, Dearborn
    • Related Report
      2016 Research-status Report
  • [Presentation] Clinical Trial of 49-Channel STS Retinal Prosthesis for Advanced RP Patients.2016

    • Author(s)
      Fujikado Takashi, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Endo Takao, Nishida Ke, Kishima H, Hirota M, Oosawa K, Ozawa M, NishidaKo
    • Organizer
      9th Biennial World Research Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision
    • Place of Presentation
      USA, Dearborn
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relationship between retinal damage and current intensity in Suprachoroidal-Transretinal Stimulation.2016

    • Author(s)
      KandaHiroyuki
    • Organizer
      2016 Taiwan-Japan Joint Symposium
    • Place of Presentation
      奈良先端科学技術大学院大学
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 間歇性外斜視における近見輻湊時の調節と斜視角の関連の両眼波面センサーを用いた検討2016

    • Author(s)
      森本壮, 神田 寛行, 広田 雅和, 遠藤 高生, 西田 幸二, 不二門尚
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都国際会館
    • Related Report
      2016 Research-status Report
  • [Presentation] 重症網膜色素変性における網膜厚とPhosphene閾値の関係2016

    • Author(s)
      遠藤高生, 不二門 尚, 広田雅和, 神田寛行, 森本壮, 西田 幸二
    • Organizer
      第70回日本臨床眼科学会
    • Place of Presentation
      京都国際会館
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of a second-generation suprachoroidal-transretinal stimulation retinal prosthesis.2016

    • Author(s)
      Kanda H, KameiM, Sakaguchi H, Endo T, Hirota M, Morimoto T, Nishida K, Kishima H, Miyoshi T, Fujikado T
    • Organizer
      medical bionics
    • Place of Presentation
      University of Queensland, Australia
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial Vision2016

    • Author(s)
      Fujikado Takashi, Kamei M, Kishima H, Morimoto T, KandaH, Sakaguchi H, Nishida K, Endo T, Lohmann TK, Maruo T, Hirota M, Oosawa K, Ozawa M
    • Organizer
      The 3rd International Symposium on Cognitive Neuroscience Robotics
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatial extent of neural responses evaluated by single-unit activities of the lateral geniculate nucleus elicited by suprachoroidal electrical stimulation.2015

    • Author(s)
      Kanda Hiroyuki, Miyoshi Tomomitsu, Morimoto Takeshi, Fujikado Takashi
    • Organizer
      Artifitial Vision 2015
    • Place of Presentation
      ドイツ、Center for Technology Aachen Europaplatz
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] STS方式人工網膜の開発2015

    • Author(s)
      神田寛行、不二門 尚
    • Organizer
      第58回自動制御連合講演会
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 視線追尾型人工視覚システムの試作とその検証2015

    • Author(s)
      里中俊太、伊藤邦彦、角谷俊文、神田寛行、大澤孝治
    • Organizer
      第51回日本眼光学学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 人工網膜の開発2015

    • Author(s)
      神田寛行
    • Organizer
      H27年度フォトニクス技術フォーラム 第1回光情報技術研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 人工網膜の現状2015

    • Author(s)
      神田寛行、不二門 尚
    • Organizer
      第5回CiNetシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Image processing using a saliency map for a 49-channel retinal prosthesis.2015

    • Author(s)
      Hiroyuki KandaTakaomi Kanda, Yukie Nagai, Takashi Fujikado
    • Organizer
      ARVO2015
    • Place of Presentation
      米国デンバー市
    • Year and Date
      2015-05-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顕著性マップを利用した人工網膜向け画像処理2015

    • Author(s)
      神田 寛行, 神田 嵩臣, 長井 志江, 浅田 稔, 不二門 尚
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Book] 《眼科臨床エキスパート》 網膜変性疾患診療のすべて 第2章総論 Ⅴ治療 C.人工網膜2016

    • Author(s)
      編集:村上 晶/吉村 長久、 分担執筆:神田 寛行
    • Total Pages
      408
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 視線検出装置、および、視覚再生補助装置2016

    • Inventor(s)
      里中俊太, 神田寛行, 不二門 尚, 森本壮
    • Industrial Property Rights Holder
      里中俊太, 神田寛行, 不二門 尚, 森本壮
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-165203
    • Filing Date
      2016-08-26
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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