| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Previous studies have shown a pivotal role of the ventral premotor cortex (PMv) in an animal model with a focal lesion of the primary motor cortex (M1) and recovery of hand movements. I found potential reorganization of PMv projections to subcortical structures in the chronic stage of M1-lesioned rhesus macaque monkey. The subcortical connections of PMv were compared between two groups of the M1-lesion and motor recovery animals and the intact animals by using biotinylated dextran amine (BDA). Lesion-recovery group showed higher numbers of BDA-labeled axons in red nucleus and deep cerebellar nuclei (particularly, the fastigial nucleus) than in the intact. In the fastigial nucleus, the BDA-labeled terminals were mainly located in the middle to caudal part with no or little expression of aldolase C, supposed to be a somatosensory region. These results suggest that the dynamic increase of PMv projections to cerebellar and red nucleus underlies long-term motor recovery after M1 lesion.
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