The role of the exercise related lactate on the corticospinal reorganization in the focal stroke rat.

• Project/Area Number: 15K16374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Showa University
• Principal Investigator: YOSHIKAWA Akira 昭和大学, 医学部, 助教 (90737355)
• Co-Investigator(Renkei-kenkyūsha): KUMADA Tatsuro 常葉大学, 保健医療学部, 教授 (00402339) ; TSUTSUI Yoshihiro 常葉大学, 保健医療学部, 教授 (50073135) ; AGATA Nobuhide 常葉大学, 保健医療学部, 講師 (00549313) ; UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912) ; HOKAMURA Kazuya 浜松医科大学, 医学部, 教授 (90436965)
• Research Collaborator: MORISHITA Saho 常葉大学, 健康プロデュース学部, 助手
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳梗塞 / 運動負荷 / 乳酸 / 皮質脊髄路

Outline of Final Research Achievements

We have studied the role of physical rehabilitation on neuronal reconstruction after cerebral infarction. To elucidate the relationship between motor dysfunction and deficits in local region of cerebral cortex, we established the focal stroke mouse and rat model, which only have small size of infarction in distinct cortical area such as motor cortex. To determine the conditions of physical rehabilitation using treadmill, we measured blood lactic acid levels, oxygen consumption and respiratory rate during exercises. As a result, increasing the intensity of treadmill exercise revealed the anaerobic and lactate threshold similar to human. Moreover, evaluation of the motor function during gait using kinesiological analysis enabled us to detect the subtle impairment of the limb's function. These results can open the possibility to access the relationship between the exercise related lactate and functional recovery.

Research Products

• [Journal Article] Coupling of dyspnea perception and occurrence of tachypnea during exercise. (2017)
  • Author(s): Tsukada S, Masaoka Y, Yoshikawa A, Okamoto K, Homma I, Izumizaki M.
  • Journal Title: J Physiol Sci. Volume: 67 Issue: 1 Pages: 173-180
  • DOI: 10.1007/s12576-016-0452-5
  • NAID: 40021064609
  • Peer Reviewed
• [Journal Article] 神経発生学的な視点から再生医療のリハビリテーションについて考える : 神経の電気的な活動を摂動するニューロリハへの可能性 (2016)
  • Author(s): 熊田 竜郎，吉川 輝
  • Journal Title: 常葉大学保健医療学部紀要 Volume: 7 Pages: 17-27
  • NAID: 40020785642
  • Peer Reviewed
• [Presentation] Altered functional connectivity of resting state fMRI by eliminating of physiological fluctuation. (2017)
  • Author(s): Akira Yoshikawa, Masaki Yoshida, Yuri Masaoka, Nobuyoshi Koiwa, Keiko Watanabe, Masahiro Ida, Masahiko Izumizaki.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松. (静岡・浜松)
  • Year and Date: 2017-03-28
• [Presentation] Effect of different exercises on neurogenesis and motor recovery in rats with motor cortex infarction. (2017)
  • Author(s): Saho Morishita, Kazuya Hokamura, Akira Yoshikawa, Nobuhide Agata, Kazuho Umemura, Yoshihiro Tsutsui, Tatsuro Kumada.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松. (静岡・浜松)
  • Year and Date: 2017-03-28
• [Presentation] Activating dorsal raphe nucleus serotonin neurons affects control of vigilance state switch. (2017)
  • Author(s): Rika Moriya, Mitsuko Kanamaru, Naoki Okuma, Akira Yoshikawa, Kenji F Tanaka, Satoshi Hokari, Yasuyoshi Oshima, Hiroshi Onimaru, Masahiko Izumizaki.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松. (静岡・浜松)
  • Year and Date: 2017-03-28
• [Presentation] Relationship between anxiety behavior and respiration control as determined using optogenetics. (2017)
  • Author(s): Naoki Okuma, Mitsuko Kanamaru, Rika Moriya, Kenji F Tanaka, Satoru Arata, Jun Watanabe, Toshiyuki Endou, Akira Yoshikawa, Makito Iizuka, Masahiko Izumizaki.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松. (静岡・浜松)
  • Year and Date: 2017-03-28
• [Presentation] Behavioral, Neuroanatomical, and DNA microarray Study after Neonatal and Adult Unilateral Brain Hemisuction Mice. (2016)
  • Author(s): Akira Yoshikawa, Tomoya Nakamachi, Hirokazu Ohtaki, Masahiko Izumizaki.
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (SFN2016)
  • Place of Presentation: San Diego Convention Center (San Diego, CA, U.S.A.)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Respiratory synchronizes activation of olfactory processing in the limbic system. (2016)
  • Author(s): Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Keiko Watanabe, Akira Yoshikawa, Masahiro Ida, Ikuo Homma, Masahiko Izumizaki.
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (SFN2016)
  • Place of Presentation: San Diego Convention Center (San Diego, CA, U.S.A.)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Responses of human mesenchymal stem/stromal cells in brain ischemia (2016)
  • Author(s): Hirokazu Ohtaki, Saki Taniguchi, Yuki Tanaka, Jun Watanabe, Kazuyuki Miyamoto, Akira Yoshikawa, Kenji Dohi, Kazuho Honda
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience (SFN2016)
  • Place of Presentation: San Diego Convention Center (San Diego, CA, U.S.A.)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 神経筋骨格モデルを用いた筋の力学特性と歩容の関係性の分析. (2016)
  • Author(s): 的場斗吾，長谷和徳，林祐一郎，金承革，吉川輝.
  • Organizer: 第37回バイオメカニズム学術講演会
  • Place of Presentation: 富山大学 (富山・射水)
  • Year and Date: 2016-11-12
• [Presentation] Transiently altered brain connectivity after cataract surgery -resting fMRI study-. (2016)
  • Author(s): Masaki Yoshida, Masahiro Ida, Yuri Masaoka, Nobuyoshi Koiwa, Akira Yoshikawa, Keiko Watanabe.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー. (埼玉・大宮)
  • Year and Date: 2016-09-09
• [Presentation] Odor induced autographical memory associated with activity in the posterior parts of the brain as well as limbic olfactory areas. (2016)
  • Author(s): Keiko Watanabe, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Akira Yoshikawa, Masahiro Ida, Mitsuru Kawamura, Kenjiro Ono, Masahiko Izumizaki.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー. (埼玉・大宮)
  • Year and Date: 2016-09-09
• [Presentation] Respiratory-related neural activities in medulla and limbic system during resting and olfactory states -fMRI study-. (2016)
  • Author(s): Yuri Masaoka, Masahiro Ida, Masaki Yoshida, Nobuyoshi Koiwa, Keiko Watanabe, Akira Yoshikawa, Ikuo Homma, Masahiko Izumizaki.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー. (埼玉・大宮)
  • Year and Date: 2016-09-09
• [Presentation] Optogenetic silencing of selected serotonin neurons in the control of CO2-induced arousal. (2016)
  • Author(s): Rika Moriya, Rika Moriya, Mitsuko Kanamaru, Naoki Ookuma, Akira Yoshikawa, Kenji F. Tanaka, Satoshi Hokari, Yasuyoshi Ohshima, Masahiko Izumizaki
  • Organizer: 26th International Congress of the European Respiratory Society.
  • Place of Presentation: ExCeL Conference Centre (Newham, London, U.K.)
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Activities of the medulla and the limbic system synchronized with respiration during olfactory stimuli -fMRI study-. (2016)
  • Author(s): Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Keiko Watanabe, Akira Yoshikawa, Masahiro Ida, Ikuo Homma, Masahiko Izumizaki
  • Organizer: 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: PACIFICO Yokohama (Yokohama, KANAGAWA)
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] 運動皮質梗塞ラットにおける運動機能回復および神経新生に対する走行運動の効果 (2016)
  • Author(s): 森下紗帆， 外村和也，吉川輝，縣信秀，梅村和夫，筒井祥博，熊田竜郎
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2016-03-22
• [Presentation] 運動皮質梗塞ラットの運動機能回復と神経新生を促がす運動負荷法の検討. (2016)
  • Author(s): 森下紗帆，外村和也，縣信秀，吉川輝，梅村和夫，筒井祥博，熊田竜郎.
  • Organizer: 第135回日本薬理学会関東部会
  • Place of Presentation: アクトシティ浜松. (静岡・浜松)