Integrated research of neural network reorganization following brain injury for clinical application
| Project/Area Number |
15K16377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kindai University |
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Principal Investigator |
TANAKA Takashi 近畿大学, 東洋医学研究所, 助教 (30734694)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳損傷 / 神経回路再建 / チロシン脱リン酸化酵素 / 運動療法 / 神経再生 / 持続的運動 / 運動機能回復 |
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| Outline of Final Research Achievements |
Plasticity is quite limited in the adult brain. We examined whether increase of neural network reorganization in mice by combining suppression of src homology 2-containing phosphatase (SHP)-1, which negatively affect axonal reorganization, with exercise.
Brain injury mice exercised for 6 weeks from 2 weeks before injury. We observed that the number of regenerative axon was increased and motor function recovery of impaired forelimb was enhanced in these combined treatment mice.
Our results indicate that downregulation of SHP-1 and the exercise promotes neural network reorganization and functional recovery after brain injury.
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Report
(3 results)
Research Products
(5 results)
