| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Plasticity is quite limited in the adult brain. We examined whether increase of neural network reorganization in mice by combining suppression of src homology 2-containing phosphatase (SHP)-1, which negatively affect axonal reorganization, with exercise.
Brain injury mice exercised for 6 weeks from 2 weeks before injury. We observed that the number of regenerative axon was increased and motor function recovery of impaired forelimb was enhanced in these combined treatment mice.
Our results indicate that downregulation of SHP-1 and the exercise promotes neural network reorganization and functional recovery after brain injury.
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