| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Rehabilitative training can improve functional recovery after stroke. Previous reports demonstrated that motor map reorganization plays pivotal role in the functional recovery induced by rehabilitative training. However, the mechanism of it was not known. In the current study, we revealed that rehabilitative forelimb training after stroke induces axonal remodeling in which corticospinal neurons originally projecting to the spinal area which innervate trunk muscle extend their axons to form new connections to the spinal area which innervate forelimb muscle. Our results suggest this axonal remodeling contributes to the motor map reorganization and functional recovery induced by rehabilitative training.
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