The mechanism of the motor map reorganization induced by rehabilitative training after stroke
Project/Area Number |
15K16382
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Kawasaki Medical School |
Principal Investigator |
Naohiko Okabe 川崎医科大学, 医学部, 助教 (30614276)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | リハビリテーション / 脳梗塞 / 皮質脊髄路 / 運動野再構成 |
Outline of Final Research Achievements |
Rehabilitative training can improve functional recovery after stroke. Previous reports demonstrated that motor map reorganization plays pivotal role in the functional recovery induced by rehabilitative training. However, the mechanism of it was not known. In the current study, we revealed that rehabilitative forelimb training after stroke induces axonal remodeling in which corticospinal neurons originally projecting to the spinal area which innervate trunk muscle extend their axons to form new connections to the spinal area which innervate forelimb muscle. Our results suggest this axonal remodeling contributes to the motor map reorganization and functional recovery induced by rehabilitative training.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] COA-Cl, a Novel Synthesized Nucleoside Analog, Exerts Neuroprotective Effects in the Acute Phase of Intracerebral Hemorrhage.2016
Author(s)
Lu F, Nakamura T, Okabe N, Himi N, Nakamura-Maruyama E, Shiromoto T, Narita K, Tsukamoto I, Xi G, Keep RF, Miyamoto O.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 25
Issue: 11
Pages: 2637-2643
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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