| Project/Area Number |
15K16386
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hamamatsu University School of Medicine (2016-2017)
National Rehabilitation Center for Persons with Disabilities (2015) |
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Principal Investigator |
Iwabuchi Toshiki 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (20711518)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | fMRI / ニューロフィードバック / 言語 / 文処理 / 脳機能計測 / 文理解 / rTMS |
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| Outline of Final Research Achievements |
This study aimed to investigate the brain mechanism of language and to explore new methods for language rehabilitation using techniques tapping into brain plasticity, such as real-time fMRI neurofeedback. We conducted two fMRI studies (Study 1 and 2) to elucidate detailed neural mechanism of sentence processing. Study 1 revealed the neural dissociation between syntactic structure building and syntactic working memory; the left pars opercularis (PO) in inferior frontal gyrus (IFG) is involved in the former, while the left op9 in frontal operculum subserves the latter. In Study 2, we demonstrated that the dorsal language pathway (i.e., the left PO and posterior middle temporal gyrus) and the ventral language pathway (i.e., the left pars triangularis in IFG and anterior temporal lobe) serve to syntactic structure building and semantic composition, respectively. On the basis of these results, we would like to develop new neurofeedback-based rehabilitation methods for syntactic deficits.
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