Investigate the mechanism of obesity and lymphedema to support the patient's life

• Project/Area Number: 15K16399
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hokkaido Bunkyo University (2016-2017); Sapporo Medical University (2015)
• Principal Investigator: SATO AKINORI 北海道文教大学, 人間科学部, 講師 (40585585)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: リンパ浮腫 / 肥満 / 運動 / 患者支援 / レプチン濃度 / 管腔形成能 / 増殖能 / IL-6 / SOCS3 / 脂肪細胞 / レプチン高濃度 / SOCS３

Outline of Final Research Achievements

It was published in a Journal of PLOS ONE in June 2016 that novel mechanisms of compromised lymphatic endothelial cell homeostasis in obesity.　This resulted in obesity supporting the mechanisms responsible for the onset of lymphoedema.
From the research results, I was able to teach proper exercise methods and daily life guidance for the patients and therapist.

Research Products

• [Journal Article] Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression (2017)
  • Author(s): Jitsukawa Sumito、Kamekura Ryuta、Kawata Koji、Ito Fumie、Sato Akinori、Matsumiya Hiroshi、Nagaya Tomonori、Yamashita Keiji、Kubo Terufumi、Kikuchi Tomoki、Sato Noriyuki、Hasegawa Tadashi、Kiyonari Hiroshi、Mukumoto Yoshiko、Takano Ken-ichi、Himi Tetsuo、Ichimiya Shingo
  • Journal Title: The Journal of Pathology Volume: 243 Issue: 3 Pages: 342-353
  • DOI: 10.1002/path.4951
  • Peer Reviewed / Open Access
• [Journal Article] Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease (2017)
  • Author(s): Kamekura Ryuta、Takano Kenichi、Yamamoto Motohisa、Kawata Koji、Shigehara Katsunori、Jitsukawa Sumito、Nagaya Tomonori、Ito Fumie、Sato Akinori、Ogasawara Noriko、Tsubomatsu Chieko、Takahashi Hiroki、Nakase Hiroshi、Himi Tetsuo、Ichimiya Shingo
  • Journal Title: The Journal of Immunology Volume: 199 Issue: 8 Pages: 2624-2629
  • DOI: 10.4049/jimmunol.1601507
  • Peer Reviewed / Open Access
• [Journal Article] Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation (2016)
  • Author(s): Sato A, Kamekura R, Kawata K, Kawada M, Jitsukawa S, Yamashita K, Sato N, Himi T, Ichimiya S
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: 1-17
  • DOI: 10.1371/journal.pone.0158408
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma (2015)
  • Author(s): Kamekura R, Shigehara K, Miyajima S, Jitsukawa S, Kawata K, Yamashita K, Nagaya T, Kumagai A, Sato A, Matsumiya H, Ogasawara N, Seki N, Takano K, Kokai Y, Takahashi H, Himi T, Ichimiya S
  • Journal Title: Clinical Immunology Volume: in press Issue: 2 Pages: 120-5
  • DOI: 10.1016/j.clim.2015.02.016
  • Peer Reviewed / Open Access
• [Presentation] A needs survey for people with breast cancer surgery after leaving hospital (2017)
  • Author(s): Takehiko Ito, Mizue Shiromaru, Migiwa Nakada, Akinori Sato and Masaya Kawada
  • Organizer: TNMC & WANS International Nursing Research Conference 2017
  • Int'l Joint Research
• [Presentation] リンパ浮腫と肥満に関する臨床と基礎の橋渡し研究 (2015)
  • Author(s): 佐藤明紀
  • Organizer: 国際リンパ浮腫フレームワーク・ジャパン研究協議会 第5回学術集会
  • Place of Presentation: 北海道大学医学部学友会館（札幌市）
  • Year and Date: 2015-09-21
• [Presentation] 肥満とリンパ浮腫発症のメカニズムの解明（臨床・基礎の橋渡し研究） (2015)
  • Author(s): 佐藤明紀
  • Organizer: 第50回日本理学療法学術大会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-06-05
• [Book] 図解 運動療法ガイド (2017)
  • Author(s): 佐藤明紀
  • Total Pages: 1301
  • Publisher: 文光堂