Analysis and Modeling of the Dynamics of Sleep Stage Transitions in Humans

• Project/Area Number: 15K16416
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental mechanisms and the body works
• Research Institution: The University of Tokyo
• Principal Investigator: Kishi Akifumi 東京大学, 大学院教育学研究科(教育学部), 助教 (70748946)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 睡眠 / 睡眠段階遷移 / 個人差 / 超日リズム / モデリング / 加齢 / 睡眠段階

Outline of Final Research Achievements

In this study, we found that (1) in healthy young adults, sleep stage transitions and ultradian rhythm of sleep exhibited significantly stable and robust interindividual differences, suggesting that mechanisms underlying the dynamics of sleep stage transitions may be considerably trait-like, (2) in healthy sleepers, sleep continuity was positively correlated with sleep duration, suggesting that mechanisms of sleep continuity may lead to individual differences in sleep duration, (3) older subjects showed decreased continuity of slow-wave sleep compared to younger subjects, and decreased slow-wave activity was associated with impaired spatial navigational memory performance, and (4) hypnograms generated by 2nd-order stage transition probabilities and stage-specific survival time function could reproduce the central position of the distribution of REM-onset intervals, suggesting that mechanism governing sleep stage transitions underlies the generation of the ultradian rhythm of sleep.

Research Products

• [Int'l Joint Research] NYU School of Medicine/Washington State University/Beth Israel Medical Center(米国)
• [Int'l Joint Research] Universidade Federal de Sao Paulo(ブラジル)
• [Int'l Joint Research] NYU School of Medicine/Washington State University(米国)
• [Journal Article] Sleep continuity is positively correlated with sleep duration in laboratory nighttime sleep recordings (2017)
  • Author(s): Kishi, A., H. P. A. Van Dongen, B. H. Natelson, A. M. Bender, L. O. Palombini, L. Bittencourt, S. Tufik, I. Ayappa, D. M. Rapoport
  • Journal Title: PLoS ONE Volume: 12 Issue: 4 Pages: e0175504-e0175504
  • DOI: 10.1371/journal.pone.0175504
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reduced slow-wave sleep is associated with high cerebrospinal fluid Aβ42 levels in cognitively normal elderly (2016)
  • Author(s): Varga AW, Wohlleber ME, Gimenez S, Romero S, Alonso JF, Ducca EL, Kam K, Lewis C, Tanzi EB, Tweardy S, Kishi A, Parekh A, Fischer E, Gumb T, Alcolea D, Fortea J, Lleo A, Blennow K, Zetterberg H, Mosconi L, Glodzik L, Pirraglia E, Burschtin OE, de Leon MJ, Rapoport DM, Lu SE, Ayappa I, Osorio RS
  • Journal Title: Sleep Volume: 39 Issue: 11 Pages: 2041-2048
  • DOI: 10.5665/sleep.6240
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of aging on slow wave sleep dynamics and human spatial navigational memory consolidation. (2016)
  • Author(s): Varga, A. W., E. L. Ducca, A. Kishi, E. Fischer, A. Parekh, V. Koushyk, P. L. Yau, T. Gumb, D. P. Leibert, M. E. Wohlleber, O. E. Burschtin, A. Convit, D. M. Rapoport, R. S. Osorio, I. Ayappa.
  • Journal Title: Neurobiology of Aging Volume: 42 Pages: 142-149
  • DOI: 10.1016/j.neurobiolaging.2016.03.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Wake-sleep transition from the perspective of cortico-thalamo-cortical loop: Electroencephalogram data analysis and simulation. (2016)
  • Author(s): Yamaguchi, I., A. Kishi., F. Togo, T. Nakamura, Y. Yamamoto.
  • Journal Title: Proceedings of the 8th International Workshop on Biosignal Interpretation Volume: - Pages: 112-115
  • Peer Reviewed
• [Journal Article] Markov modeling of sleep stage transitions and ultradian REM sleep rhythm: A simulation study. (2016)
  • Author(s): Kishi, A., I. Yamaguchi, F. Togo, Y. Yamamoto.
  • Journal Title: Proceedings of the 8th International Workshop on Biosignal Interpretation Volume: - Pages: 108-111
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ヒト睡眠段階遷移のダイナミクスとNREM/REM睡眠超日リズムの生成機序 (2016)
  • Author(s): 岸哲史，東郷史治，山本義春
  • Organizer: 第23回日本時間生物学会学術大会
  • Place of Presentation: 愛知
  • Year and Date: 2016-11-13
  • Invited
• [Presentation] Markov modeling of sleep stage transitions and ultradian REM sleep rhythm (2016)
  • Author(s): 岸哲史，山口郁博，東郷史治，山本義春
  • Organizer: 計測自動制御学会ライフエンジニアリング部門シンポジウム2016
  • Place of Presentation: 大阪
  • Year and Date: 2016-11-05
• [Presentation] Wake-sleep transition from the perspective of cortico-thalamo-cortical loop: Electroencephalogram data analysis and simulation. (2016)
  • Author(s): Yamaguchi, I., A. Kishi, F. Togo, T. Nakamura, Y. Yamamoto
  • Organizer: The 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] Markov modeling of sleep stage transitions and ultra- dian REM sleep rhythm: A simulation study (2016)
  • Author(s): Kishi, A., I. Yamaguchi, F. Togo, Y. Yamamoto.
  • Organizer: The 8th International Workshop on Biosignal Interpretation
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-11-02
  • Int'l Joint Research
• [Presentation] An EEG analysis method to estimate the thalamocortical connectivity. (2016)
  • Author(s): Yamaguchi, I., A. Kishi, F. Togo, T. Nakamura, Y. Yamamoto.
  • Organizer: 1st International Conference on Sleep Spindling
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2016-05-14
  • Int'l Joint Research
• [Presentation] 就寝中覚醒の確率過程モデリング ―脳波による視床-皮質間結合強度の解析結果から― (2016)
  • Author(s): 山口郁博，東郷史治，岸哲史，中村亨，山本義春
  • Organizer: 第55回日本生体医工学会大会
  • Place of Presentation: 富山
  • Year and Date: 2016-04-28
• [Presentation] Effects of aging on slow wave sleep dynamics and human spatial navigational memory consolidation (2015)
  • Author(s): Varga, A. W., E. L. Ducca, A. Kishi, A. Parekh, E. Fischer, V. Koushyk, T. Gumb, D. P. Leibert, O. E. Burschtin, A. Convit, R. S. Osorio, I. Ayappa, D. M. Rapoport.
  • Organizer: 14th International Symposium on Sleep and Breathing
  • Place of Presentation: Pernambuco, Brazil
  • Year and Date: 2015-10-28
  • Int'l Joint Research
• [Presentation] The wake-sleep transition as an opening of the cortico-thalamic loop (2015)
  • Author(s): 山口郁博，東郷史治，岸 哲史，中村 亨，山本義春
  • Organizer: 計測自動制御学会ライフエンジニアリング部門シンポジウム2015（第30回生体・生理工学シンポジウム）
  • Place of Presentation: 福岡
  • Year and Date: 2015-09-02
• [Presentation] Wake-Sleep Transition as an Opening of Cortico-Thalamo-Cortical Loop (2015)
  • Author(s): Yamaguchi, I., F. Togo, A. Kishi, T. Nakamura, Y. Yamamoto.
  • Organizer: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano, Italy
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] ヒト睡眠段階遷移のダイナミクス (2015)
  • Author(s): 岸 哲史
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木
  • Year and Date: 2015-07-03
  • Invited
• [Presentation] Effects of aging on slow wave sleep disruption and reduced overnight consolidation of spatial navigational memory (2015)
  • Author(s): Varga, A. W., E. L. Ducca, D. P. Leibert, J. Lim, A. Kishi, V. Koushyk, T. Gumb, A. Parekh, R. S. Osorio, O. E. Burschtin, D. M. Rapoport, I. Ayappa.
  • Organizer: The SLEEP 2015 29th Annual Meeting of the Associated Professional Sleep Societies, LLC.
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2015-06-08
  • Int'l Joint Research