Athlete support systems using genetic characteristics

• Project/Area Number: 15K16467
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Nippon Sport Science University
• Principal Investigator: KIKUCHI Naoki 日本体育大学, 体育学部, 助教 (10739478)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 遺伝子多型 / パフォーマンス / アスリート / ACTN3 / MCT1 / 競技実績

Outline of Final Research Achievements

The aim of the present study were 1) to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Japanese cohort of track and field athletes. 2) to investigate the effects of the MCT1 T1470A polymorphism on power-oriented performance and lactate concentration during or after cycling sprints in Japanese wrestlers. One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls in study 1 and 199 wrestlers in study 2 were genotyped for ACTN3 R577X genotype and e MCT1 T1470A genotype using the TaqMan Assay. The data obtained for track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status. The AA genotype of the MCT1 T1470A polymorphism is associated with athletic performance and lower blood lactate concentrations after 30s WAnT and during intermittent sprint tests.

Research Products

• [Journal Article] The association between MCT1 T1470A polymorphism and power-oriented athlete performance (2017)
  • Author(s): Kiluchi N, Fuku N, Matsumoto R, Murakami H, Miyachi M, Nakazato K
  • Journal Title: Int J Sports Med Volume: 38 Issue: 01 Pages: 76-80
  • DOI: 10.1055/s-0042-117113
  • Peer Reviewed
• [Journal Article] Heritability estimates of muscle strength-related phenotypes: A systematic review and meta-analysis. (2017)
  • Author(s): Zempo H, Miyamoto-Mikami E, Kikuchi N, Fuku N, Miyachi M, Murakami H.
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 印刷中 Issue: 12 Pages: 1537-1546
  • DOI: 10.1111/sms.12804
  • Peer Reviewed / Open Access
• [Journal Article] Association between ACTN3 R577X polymorphism and trunk flexibility in tow different cohorts. (2017)
  • Author(s): Kikuchi N, Zempo H, Fuku N, Murakami H, Sakamaki-Sunaga M, Okamoto T, Nakazato K, Miyachi M.
  • Journal Title: International Journal Sports Medicine Volume: 38 Issue: 05 Pages: 402-406
  • DOI: 10.1055/s-0042-118649
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes (2016)
  • Author(s): Kikuchi N, Miyamoto-Mikami E, Murakami H, Nakamura T, Min SK, Mizuno M, Naito H,Miyachi M, Nakazato K, Fuku N.
  • Journal Title: European Journal of Sports Science Volume: 16 Pages: 694-701
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of high-intensity interval cycling sprints subsequent to arm-curl exercise on upper-body muscle strength and hypertrophy. (2016)
  • Author(s): Kikuchi N, Yoshida S, Okumura M, Nakazato K.
  • Journal Title: Journal of Strength and Conditioning Research Volume: 30
  • Peer Reviewed
• [Journal Article] 運動能力•運動行動の遺伝率 (2016)
  • Author(s): 村上晴香、膳法浩史、宮本（三上）恵里、菊池直樹、福典之
  • Journal Title: 体力科学 Volume: 65
  • NAID: 130005151198
• [Journal Article] ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes (2016)
  • Author(s): Kikuchi N, Miyamoto-Mikami E, Murakami H, Nakamura T, Min SK, Mizuno M, Naito H,Miyachi M, Nakazato K, Fuku N
  • Journal Title: European Journal of Sports Science Volume: 16
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effective utilization of genetic information for athletes and coaches: focus on the ACTN3 R577X polymorphism. (2015)
  • Author(s): Kikuchi N and Nakazato K
  • Journal Title: Journal of Exercise Nutrition and Biochemistry Volume: 19 Issue: 3 Pages: 157-164
  • DOI: 10.5717/jenb.2015.15093001
  • Open Access
• [Journal Article] ACTN3 R577X genotype is associated with muscle function in a Japanese population (2014)
  • Author(s): Kikuchi N, Yoshida S, Min SK, Lee K. Sakamaki-Sunaga M, Okamoto T, Nakazato K.
  • Journal Title: Applied Physiology Nutrition and Metabolism Volume: 40 Issue: 4 Pages: 316-322
  • DOI: 10.1139/apnm-2014-0346
  • Peer Reviewed / Open Access
• [Presentation] Low load bench press and push up with similar intensity induce comparable muscle hypertrophy and strength gain in untrained men. (2016)
  • Author(s): Kikuchi N, Okuyama M, Nakazato K.
  • Organizer: 21th European Congress of Sports Science.
  • Place of Presentation: Austria Center Vienna（ウィーン、オーストリア）
  • Year and Date: 2016-07-06
  • Int'l Joint Research
• [Presentation] The AGTR2 rs11091046 Polymorphism Is Associated with Elite Japanese and Jamaican Sprint/Power Athlete Status. (2016)
  • Author(s): Yvert T, Zempo H, Kikuchi N, Miyamoto-Mikami E, Wang G, Murakami H, Naito H, Miyachi M, Pitsiladis Y, Fuku N.
  • Organizer: ACSM 63th Annual meeting
  • Place of Presentation: Hynes Convention Center（ボストン、アメリカ）
  • Year and Date: 2016-06-01
  • Int'l Joint Research
• [Presentation] MCT1 A1470T Polymorphism Is Associated With Power-oriented Athletic Performance In Elite Japanese Wrestlers. (2015)
  • Author(s): Kikuchi N, Fuku N, Matsumoto R, Matsumoto S, Murakami H, Miyachi M and Nakazato K.
  • Organizer: ACSM 62th Annual meeting
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Remarks] 日本体育大学トレーニング研究室
  • URL: http://knuckledown731.wix.com/mysite