| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Smoking is considered an environmental aging accelerator. While aging is unavoidable, the aging mechanism is still unclear because of its complexity. We focused on the anti-aging protein alpha-Klotho and the beta-Klotho-associated protein fibroblast growth factor (FGF)-21 to evaluate the acceleration of aging induced by smoking habit. From the study, we found that smoking simultaneously increases two Klotho-related molecules; alpha-Kltho and FGF-21, in male subjects. We speculate that acceleration of aging induced by smoking can be explained from two aspects, inflammation and metabolic disorders, respectively associated with alpha-Klotho and FGF-21.
Moreover, we examined sex differences of these Klotho-related molecules. We found that Klotho-related molecules showed a differential association and response to smoking between men and women.
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