| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
Although there is exercise therapy as treatment and prevention of diabetes, the influence on intramyocellular lipid (IMCL) due to difference in exercise intensity is unclear. We recruited 20 men and randomly assigned to low intensity exercise(LIE) or vigorus intensity exercise (VIE) group. Each group performed with ergometer for 5 consecutive days. Before and 3-day after completion of protocol, Insulin resistance (IR) was evaluated by glucose clamp. IMCL was measured by 1H-MRS. Both exercise protocol improved IR. IMCL level did not notice any significant change in LIE group, that in VIE group increased from baseline. These data suggested exercise intensity is a determinant of change of IMCL.
From the mass analysis of the muscle biopsy sample, the fat component / mass accumulated by LIE and VIE group were different. Based on these findings, it was confirmed that the fat mass components and mass differed differently due to differences in exercise intensity.
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