Mechanisms underlying the anti-inflammatory activity of molecular hydrogen via chemical modification of mitochondrial biomolecules
Project/Area Number |
15K16524
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Applied health science
|
Research Institution | Seikei University (2017) Nippon Medical School (2015-2016) |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 抗炎症作用 / 細胞膜 / ミトコンドリア / フリーラジカル連鎖反応 / 分子状水素 / 脂質過酸化 / 細胞死 / 脂肪酸 / 酸化ストレス / 生体分子 / 炎症 |
Outline of Final Research Achievements |
In this study, we investigated the mechanism underlying the anti-inflammatory activity of molecular hydrogen via the regulation of biomolecules in the mitochondria. Molecular hydrogen regulated the gene expression and cell death by modifying the free radical chain reaction-dependent generation of oxidized lipid mediators.
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Report
(4 results)
Research Products
(28 results)