Mechanism of anti-inflammatory action of molecular hydrogen from epigenetic control

• Project/Area Number: 15K16525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Waseda University (2017); Nippon Medical School (2015-2016)
• Principal Investigator: lee hyunjin 早稲田大学, ナノ・ライフ創新研究機構, その他(招聘研究員) (80734441)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 活性酸素種 / 水素 / エピジェネティクス / 抗酸化物質 / 活性酸素類 / エピジェネティック

Outline of Final Research Achievements

The purpose of this study is to elucidate the anti oxidant efffect mechanism of hydrogen through confirming the effect of molecular hydrogen on epigenetic abnormality in lifestyle - related diseases.
Cells were used to ascertain the effect of molecular hydrogen under conditions causing epigenetic abnormality. As a result, it was confirmed that molecular hydrogen changes epigenetics including activation of HDAC. However, it was not possible to examine the effect of moluecular hydrogen by using a high-fat diet intake animal model, and the existence of epigenetic change in an animal model has time to establish a methodology, and at the stage of comparing and examining It did not arrive.

Research Products

• [Journal Article] Acute immobilization stress following contextual fear conditioning reduces fear memory: timing is essential (2019)
  • Author(s): Akemi Uwaya, Hyunjin Lee, Jonghyuk Park, Hosung Lee, Junko Muto, Sanae Nakajima, Shigeo Ohta,Toshio Mikami
  • Journal Title: Behavioral and Brain functions Volume: 12 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s12993-016-0092-1
  • Peer Reviewed / Open Access
• [Journal Article] Intermittent intense exercise protects against cognitive decline in a similar manner to moderate exercise in chronically stressed mice (2018)
  • Author(s): Lee Hyunjin、Nagata Kazufumi、Nakajima Sanae、Ohno Makoto、Ohta Shigeo、Mikami Toshio
  • Journal Title: Behavioural Brain Research Volume: 345 Pages: 59-64
  • DOI: 10.1016/j.bbr.2018.01.017
  • Peer Reviewed
• [Journal Article] Highly dispersible and bioavailable curcumin but not native curcumin induces brown-like adipocyte formation in mice. (2018)
  • Author(s): Nishikawa, S., Kamiya, M., Aoyama, H., Nomura, M., Hyodo, T., Ozeki, A., Lee, H,, Takahashi, T., Imaizumi, A., Tsuda, T.
  • Journal Title: Mol. Nutr. Food Res. Volume: 62 Issue: 5 Pages: 1700731-1700731
  • DOI: 10.1002/mnfr.201700731
  • Peer Reviewed
• [Journal Article] Taheebo Polyphenols Attenuate Free Fatty Acid-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of Cyclooxygenase-2 (2017)
  • Author(s): Ma Sihui、Yada Koichi、Lee Hyunjin、Fukuda Youichi、Iida Akira、Suzuki Katsuhiko
  • Journal Title: Frontiers in Nutrition Volume: 4 Pages: 1-11
  • DOI: 10.3389/fnut.2017.00063
  • Peer Reviewed / Open Access
• [Presentation] ぶどう種子ポリフェノール、アカシアポリフェノールの抗炎症作用および選択的シクロオキゲナーゼ抑制作用に関する検討 (2017)
  • Author(s): 馬 思慧,矢田 光一,Lee hyunjin, 鈴木 克彦
  • Organizer: 代替補完医療学会
• [Presentation] Molecular hydrogen regulates gene expression by modifying the free radical chain reaction- dependent generation of oxidized phospholipid mediators (2015)
  • Author(s): 井内勝哉、井本明美、西槙貴代美、一宮直美、Lee Hyunjin,横田隆、上村尚美、太田成男
  • Organizer: 第38回日本分子生物学会 第88回日本生化学会 合同学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2015-12-01
• [Presentation] TBHPを用いた酸化ストレス誘導性の細胞死に対する分子状水素の保護作用 (2015)
  • Author(s): 井内勝哉、井本明美、西槙貴代美、一宮直美、Lee Hyunjin,横田隆、上村尚美、太田成男
  • Organizer: 第24回日本Cell Death 学会 学術集会
  • Place of Presentation: 大阪大学会館
  • Year and Date: 2015-07-11
• [Remarks] 日本医科大学 先端医学研究所 細胞生物学部門
  • URL: http://home.nms.ac.jp/ig/saiboseibutsu/index.html