| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have reported that hypothalamic orexin-A-induced activation of vagus nerve recovered the development of post-ischemic glucose intolerance and mediates a neuroprotective effect. The aim of this study was to determine the involvement of orexin-A and vagus nerve on the changes in cerebral ischemia-induced inflammatory signaling. Male ddY mice were subjected to 2 hr of middle cerebral artery occlusion (MCAO). Intrahypothalamic OXA (5 pmol/mouse) administration significantly suppressed the development of post-ischemic glucose intolerance on day 1 after MCAO. In the liver, MCAO-induced increase in TNF-α, IL-1β, c-Jun N-terminal kinase and serine-phosphorylated insulin receptor substrate on day 1 was recovered to control levels by OXA, and which was reversed by hepatic vagotomy. These results suggest that hypothalamic orexin-A-induced activation of vagus nerve may play an important role in the regulation of post-ischemic changes in hepatic inflammatory signaling.
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